| Gene name: | HES1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | Caco-2,SW48 |
| Gene ID: | 3280 |
| Category: | protein coding |
| Phenotype: | Colorectal cancer |
| Experimental category: | L |
| PMID: | 26650241 |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | We knocked down Hes1 in SW48 and Caco2 cells and observed significantly more beta-galactosidase expression in Hes1 knocked down cells, suggesting more senescence in the Hes1depleted cells. |
| Regulatory pathway: | STAT3-MMP14 |
| R-AG-Pathway: | -- |
| Official symbol(s): | STAT3-MMP14 |
| Pathway experiment: | Western blot//qRT-PCR//Knockdown |
| Pathway description: | We observed that only MMP14 expression level decreased upon Hes1 knockdown at the mRNA level in Caco2 cells. We then found knock-down Hes1 lead to MMP14 protein level decrease in SW48 cells.Hes1 depletion resulted in a decrease of STAT3 phosphorylation and no change of total STAT3 in the Caco2 and SW48 cells. |
Annotation:
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