| Gene name: | GRB2 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | H1299,SPCA1 |
| Gene ID: | 2885 |
| Category: | protein coding |
| Phenotype: | Lung cancer |
| Experimental category: | L |
| PMID: | 30069987 |
| Experiment: | SA-β-gal activity assay//Flow cytometry |
| Description: | Up‐regulation of GRB2 effectively counteracted the inhibitory effect of miR‐1258 up‐regulation on H1299 cell proliferation. Similarly, GRB2 down‐regulation in SPCA1 cells reversed the proliferation‐promoting effect of low expression levels of miR‐1258. Moreover, it was found that up‐regulation of GRB2 suppressed cellular senescence and apoptosis, whereas the down‐regulation of GRB2 had an opposite effect. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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