| Gene name: | TGFB1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | Embryo |
| Cell name: | MEF |
| Experiment: | SA-β-gal activity assay//Immunofluorescence |
| Description: | Disruption of TGF-β signaling by E-616452 restored H4K20me3 levels, attenuated SA-β-gal staining and enhanced the Mki67 signals in Suv4-20h-depleted cells. |
| Target gene: | MIR-29//H4K20ME3 |
| Official symbol(s): | MIR-29//H4K20ME3 |
| R-AG-Target gene: | Upregulation//Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot//qRT-PCR |
| Target gene description: | Activation of TGF-β signaling by oxidative stress was accompanied by increased miR-29 accumulation and accelerated reduction in the abundance of total H4K20me3 .Furthermore, inhibition of TGF-β signaling by inhibitor treatment and Smad4 depletion diminished miR-29 expression, attenuated the reduction in Suv4-20h1 and Suv4-20h2 expression and produced partial recovery of H4K20me3. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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