Aging Overview

Aging gene

Gene name: SUSD2
Aging type: Prevent
Aging characteristic:
Tissue type: --
Cell name: Ishikawa
Gene ID: 56241
Category: protein coding
Phenotype: Endometrial cancer
Experimental category: L
PMID: 28841682
Experiment: SA-β-gal activity assay//Knockdown
Description: SiRNA-SUSD2 significantly increased blue staining indicative of SA-β-Gal activity and thus senescent cells.


Regulatory relationship

Target gene: TGFβ//SMAD2/3//LGALS1
Official symbol(s): TGFB1//SMAD2//LGALS1
R-AG-Target gene: Downregulation//--//--
Subcategory: Unclear
Target gene experiment: Western blot//Knockdown
Target gene description: At 72h TGFβ significantly decreased the number of SUSD2+ cells. The significant decrease of SUSD2 at protein level was paralleled by a similar decline of SUSD2 mRNA level.To our surprise, levels of SMAD2/3 were significantly increased upon SUSD2 knockdown. We next examined the expression of MKi67 and LGALS1 gene (the interaction partner for SUSD2).As a result, LGALS1 was significantly reduced upon SUSD2 knockdown.Moreover, MKi67 encoding the proliferation marker Ki-67 antigen, was significantly attenuated upon SUSD2 knockdown.



Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

Loading,please wait...