Gene name: | SUSD2 |
Aging type: | Prevent |
Aging characteristic: |
Tissue type: | -- |
Cell name: | Ishikawa |
Gene ID: | 56241 |
Category: | protein coding |
Phenotype: | Endometrial cancer |
Experimental category: | L |
PMID: | 28841682 |
Experiment: | SA-β-gal activity assay//Knockdown |
Description: | SiRNA-SUSD2 significantly increased blue staining indicative of SA-β-Gal activity and thus senescent cells. |
Target gene: | TGFβ//SMAD2/3//LGALS1 |
Official symbol(s): | TGFB1//SMAD2//LGALS1 |
R-AG-Target gene: | Downregulation//--//-- |
Subcategory: | Unclear |
Target gene experiment: | Western blot//Knockdown |
Target gene description: | At 72h TGFβ significantly decreased the number of SUSD2+ cells. The significant decrease of SUSD2 at protein level was paralleled by a similar decline of SUSD2 mRNA level.To our surprise, levels of SMAD2/3 were significantly increased upon SUSD2 knockdown. We next examined the expression of MKi67 and LGALS1 gene (the interaction partner for SUSD2).As a result, LGALS1 was significantly reduced upon SUSD2 knockdown.Moreover, MKi67 encoding the proliferation marker Ki-67 antigen, was significantly attenuated upon SUSD2 knockdown. |
Annotation:
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