| Gene name: | ZEB1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | EPC1-hTERT |
| Gene ID: | 6935 |
| Category: | protein coding |
| Phenotype: | Endometrial cancer |
| Experimental category: | L |
| PMID: | 20424117 |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | Stable knockdown of either ZEB1 or ZEB2 resulted in upregulation of p15INK4B and p16INK4A, accompanied by transcriptional activation of the respective promoters, and senescence in a subset of the cells, indicating the possibility that ZEB may mitigate EGFR-induced senescence. |
| Target gene: | P15INK4B//P16 |
| Official symbol(s): | P15INK4B//P16 |
| R-AG-Target gene: | Upregulation//Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | ZEB1 or ZEB2 resulted in upregulation of p15INK4B and p16INK4A, accompanied by transcriptional activation of the respective promoters. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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