| Gene name: | FAHD1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HUVEC |
| Experiment: | SA-β-gal activity assay//Western blot//Knockdown |
| Description: | Furthermore,depletion of FAHD1 induced premature senescence in HUVEC, as shown by an increased percentage of cells staining positive for senescence-associated β galactosidase (SA-β-gal) .We found that the levels of both senescence marker proteins were significantly down-regulated in FAHD1-depleted cells.These findings suggest that FAHD1 is required for cell proliferation in human endothelial cells and its inactivation induces premature senescence. |
| Target gene: | P53//P21/WAF1 |
| Official symbol(s): | P53//P21/WAF1 |
| R-AG-Target gene: | --//-- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | Of note, we observed slightly increased p53 protein levels in FAHD1-depleted cells, which were accompanied by a significant increase in the level of the cdk inhibitor p21Cip1/Waf-1, which is known to contribute to the senescence-associated proliferation arrest. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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