Aging Overview

Aging gene

Gene name: FOXO1
Aging type: Accelerate
Aging characteristic:
Tissue type: --
Cell name: T98G,LN-18
Gene ID: 2308
Category: protein coding
Phenotype: Glioblastoma
Experimental category: L
PMID: 29207098
Experiment: Flow cytometry//MTT assay//Knockdown
Description: The results revealed that the overexpression of FOXO1 arrested the cell cycle in the G0/G1 phase, suppressing cells from entering the S phase. The depletion of FOXO1 increased the colony forming ability in cell proliferation of the LN18 and T98G cells.


Regulatory relationship

Target gene: SIRT1//P16
Official symbol(s): SIRT1//P16
R-AG-Target gene: Downregulation//Upregulation
Subcategory: Unclear
Target gene experiment: CHIP//Western blot//qRT-PCR
Target gene description: A ChIP assay was performed with FOXO1 antibody, which revealed that the SIRT1 promoter region interacted with FOXO1.In LN18 cells overexpressing FOXO1, the expression of SIRT1 was suppressed.The opposite results were obtained in the FOXO1-depleted cells, which showed SIRT1 was increased and p16INK4a was decreased .The mRNA levels of SIRT1 and p16INK4a were also regulated by FOXO1, which suggested that FOXO1 regulated SIRT1 and p16INK4a at the transcriptional level.

Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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