| Gene name: | ATM |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HUVEC |
| Gene ID: | 472 |
| Category: | protein coding |
| Phenotype: | Chronic obstructive pulmonary disease |
| Experimental category: | L |
| PMID: | 23897750 |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | Inhibition of ATM caused a significant increase in SIRT1 mRNA and protein levels and a reduction in SA-β-gal activity compared to control cells. Inhibition of ATM, in H2O2-treated HUVEC induced a significant increase in SIRT1 protein levels and reduction in senescence compared to control siRNA-treated cells. |
| Target gene: | SIRT1 |
| Official symbol(s): | SIRT1 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | Inhibition of ATM, in H2O2-treated HUVEC induced a significant increase in SIRT1 protein levels and reduction in senescence compared to control siRNA-treated cells. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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