| Gene name: | SKP2 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | PC-3 |
| Gene ID: | 6502 |
| Category: | protein coding |
| Phenotype: | Prostate cancer |
| Experimental category: | HL |
| PMID: | 25596733 |
| Experiment: | SA-β-gal activity assay |
| Description: | As predicted, a striking increase of β-galactosidase was found in PC3-shSKP2 cells, as compared to that in PC3-scrambled cells, in agreement with literature that SKP2 deficiency induces cellular senescence. |
| Target gene: | JARID1B |
| Official symbol(s): | KDM5B |
| R-AG-Target gene: | Inhibition |
| Subcategory: | Ubiquitylation |
| Target gene experiment: | Western blot |
| Target gene description: | SKP2 ablation resulted in a striking increase of JARID1B compared to the control. Quantification analysis revealed that JARID1B levels in PC3-shSKP2 cells were 4-fold higher than that in control cells. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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