| Gene name: | BRCA1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HBLpS,MCF-7pS,HBLpS-BR,MCF-7pS-BR,HCC1937,HCC+BR |
| Gene ID: | 672 |
| Category: | protein coding |
| Phenotype: | Breast cancer |
| Experimental category: | L |
| PMID: | 19372557 |
| Experiment: | Western blot//SA-β-gal activity assay//BrdU assay |
| Description: | Accordingly to cytologic data, BRCA1-defective cells showed also a more pronounced induction of the cyclin-dependent kinase inhibitor p21 (CDKN1A) after challenging with MMC, supporting a cell cycle arrest.In fact, treatment with MMC or CDDP resulted in a statistically significant increase in the number of elements showing hallmarks of senescence(enlarged cytoplasm, polynucleation, senescence-associated β-galactosidase positivity, and negativity for BrdUrd incorporation) in BRCA1-defective cells compared with control cells. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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