Aging Overview

Aging gene

Gene name: EID3
Aging type: Accelerate
Aging characteristic:
Tissue type: --
Cell name: MCF-7
Gene ID: 493861
Category: protein coding
Phenotype: Breast cancer
Experimental category: HL
PMID: 30114644
Experiment: SA-β-gal activity assay
Description: Induction of EID3 expression with doxycycline augmented the effects of IR on the cells, resulting in a significant increase in the induction of SA-β-gal positive senescent cells compared to the cells exposed to IR alone without the induction of EID3 by doxycycline.


Regulatory relationship

Target gene: P21//P57
Official symbol(s): P21//P57
R-AG-Target gene: Upregulation//Upregulation
Subcategory: Unclear
Target gene experiment: qRT-PCR//Western blot
Target gene description: The increase in p21 and p57 expression was augmented by the induction of EID3 with doxycycline.

Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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