| Gene name: | SOX21 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | Brain |
| Cell name: | GBM |
| Gene ID: | 11166 |
| Category: | protein coding |
| Phenotype: | Glioblastoma |
| Experimental category: | HL |
| PMID: | 28687615 |
| Experiment: | GO analysis//SA-β-gal activity assay |
| Description: | Interestingly, analysis of the genes upregulated by SOX5/6/21 instead resulted in a significant enrichment of GO-terms associated with general tumor suppressor responses, including Apoptotic process , Cellular response to stress Direct p53 effector and Senescence and Autophagy.Furthermore, forced expression of SOX5/6/21 significantly increased the number of cells that entered senescence in the three human primary GBM cell lines (KS4, G3 and #87), as measured by senescence associated gal-activity (SA-βgal) and the cleavage of X-gal. |
| Target gene: | P53 |
| Official symbol(s): | P53 |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | Notably, despite a robust increase in p53 protein levels upon forced SOX21 expression, a corresponding upregulation of TP53 gene expression could not be detected. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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