| Gene name: | TWIST1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | NPTX,HPr-1 |
| Experiment: | SA-β-gal activity assay |
| Description: | Higher percentage of SA-β-gal-positive cells was found in the Sh-TWIST transfectants (filled columns) compared with the controls (open columns) in response to both agents in a dose-dependent manner. |
| Target gene: | P14 |
| Official symbol(s): | P14 |
| R-AG-Target gene: | Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | Reverse transcriptase–polymerase chain reaction analysis showed that the expression of TWIST was also up-regulated at transcription level which was associated with down-regulation of p14 ARF (right panel). We also found that the p14 ARF expression levels were much lower in the TWIST over-expressing cells, either before or after exposure to H 2 O 2 and CP (right panels), compared with the vector control, confirming the negative effect of TWIST on p14 ARF. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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