| Gene name: | HIC1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | TPC-1 |
| Experiment: | Flow cytometry//SA-β-gal activity assay//CCK-8 assay |
| Description: | The number of cells in the G1 phase in the HIC1 transfected group (69.86 ± 1.22%) was slightly higher than in untransfected TPC-1 cells (62.36 ± 1.45%). The levels of β-galactosidase staining were also greater in the HIC1 overexpressing cells than the control TPC-1 cells. Cell proliferation in the HIC1 transfected group was significantly lower than in controls. |
| Target gene: | SIRT1 |
| Official symbol(s): | SIRT1 |
| R-AG-Target gene: | Downregulation |
| Subcategory: | Binding to promoter |
| Target gene experiment: | qRT-PCR//Western blot |
| Target gene description: | The SIRT1 mRNA and protein expression levels were lowers in the HIC1 transfected group than in untransfected cells,showing that increased expression of HIC1 downregulated expression of the SIRT1 gene in TPC-1 cells. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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