| Gene name: | BMI1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | UCB-MSC |
| Experiment: | Western blot//SA-β-gal activity assay//MTT assay |
| Description: | The overexpression of BMI1 and the decreased expression of p16INK4a was confirmed via western blotting. BMI1-overexpressing hUCB-MSCs showed a reduced SA-β-gal activity compared to that of the control GFP-transduced cells.The depletion of BMI1 increased SA-β-gal staining and p16INK4a expression, showing the accelerated aging of these hUCB-MSCs. Cellular proliferation was also decreased in shBMI1-MSCs. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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