| Gene name: | TERF1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | Bone marrow,Peripheral blood |
| Cell name: | Bone marrow cell |
| Gene ID: | 7013 |
| Category: | protein coding |
| Phenotype: | Bone marrow failure |
| Experimental category: | L |
| PMID: | 22932806 |
| Experiment: | SA-β-gal activity assay//Telomere length assay//Knockdown |
| Description: | To directly assess induction of senescence in vivo caused by TRF1 deletion, we used SA-β-gal actosidase staining directly on freshly isolated bone marrow cells.TRF1flox/floxMx1-Cre mice undergoing long-term Cre-induction/TRF1 deletion showed a dramatic telomere shortening of approximately 15 kb within 7-9 weeks of treatment in comparison with TRF1flox/floxMx1-wt mice after 13 weeks of treatment. |
| Target gene: | P53//P21 |
| Official symbol(s): | P53//P21 |
| R-AG-Target gene: | --//-- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot//Immunostaining |
| Target gene description: | We found significantly greater p53 levels in pI-pC–treated TRF1flox/floxMx1-Cre mice compared with similarly treated TRF1flox/floxMx1-wt controls;a significant increase in p21 protein levels in the treated TRF1flox/floxMx1Cre group compared with the TRF1flox/floxMx1-wt controls. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
Loading,please wait...