Aging Overview

Aging gene

Gene name: BCL6
Aging type: Prevent
Aging characteristic: Others
Tissue type: --
Cell name: MEF
Gene ID: 604
Category: protein coding
Phenotype: Aging
Experimental category: L
PMID: 11914273
Experiment: Survival curve
Description: Importantly, when expressed in primary MEFs of FVB genetic background (at 37°C), BCL6 was very efficient in inhibiting both spontaneous senescence and premature senescence induced by a RASV12oncogene .


Regulatory relationship

Target gene: CYCLIN D1
Official symbol(s): CYCLIN D1
R-AG-Target gene: Upregulation
Subcategory: Unclear
Target gene experiment: Western blot
Target gene description: The cyclin D1 protein level is up-regulated by BCL6 in three different cell types.This up-regulation of cyclin D1 is at the level of transcription, as cyclin D1 mRNA was also increased by BCL6 in MEFs.

Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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