| Gene name: | IFNA1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HDF |
| Experiment: | SA-β-gal activity assay |
| Description: | Consistent with these observations, the knockdown of IFNα/βRα subunit expression decreased the number of SA-β-gal positive cells, which is indicative of the onset of cellular senescence in HDFs. |
| Target gene: | IFI16//IL-1β//AIM2 |
| Official symbol(s): | IFI16//IL1B//AIM2 |
| R-AG-Target gene: | --//Upregulation//-- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | Similarly, the knockdown reduced basal and IFN-β induced levels of IFI16 protein.Interestingly, the treatment also increased levels of the cleaved IL-1β, a proinflammatory cytokine, which is indicative of the activation of an inflammasome.The knockdown of AIM2 expression in BPH-1 cells increased steady-state levels of STAT1 and potentiated IFN-g induced activation of STAT1. Importantly, the knockdown increased basal and the IFNg induced levels of the IFI16 protein. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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