| Gene name: | CAV1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | Osteoarthritic Chondrocyte |
| Gene ID: | 857 |
| Category: | protein coding |
| Phenotype: | Osteoarthritis |
| Experimental category: | L |
| PMID: | 16508959 |
| Experiment: | SA-β-gal activity assay |
| Description: | Pretreatment with caveolin 1 antisense ODN significantly inhibited the up-regulation of caveolin 1 expression induced by IL-1β and H2O2 (n = 4) and also significantly blocked the increase in SA–β-gal activity induced by IL-1β and H2O2 (n = 4). |
| Target gene: | P38MAPK//CII |
| Official symbol(s): | P38MAPK//CII |
| R-AG-Target gene: | Upregulation//Downregulation |
| Subcategory: | Phosphorylation |
| Target gene experiment: | Western blot//qRT-PCR//ELISA |
| Target gene description: | Compared with chondrocytes transfected with empty vectors, the chondrocytes transduced with caveolin 1 cDNA showed higher levels of phospho–p38 MAPK and lower levels of phospho–ERK-1/2. In addition, caveolin 1 overexpression impaired the ability of chondrocytes to express CII (n = 4) and aggrecan (n = 4). |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
Loading,please wait...