Aging Overview

Aging gene

Gene name: EZH2
Aging type: Prevent
Aging characteristic:
Tissue type: --
Cell name: SGC-7901
Gene ID: 2146
Category: protein coding
Phenotype: Gastric cancer
Experimental category: L
PMID: 24588771
Experiment: SA-β-gal activity assay//Flow cytometry//Knockdown
Description: EZH2 depletion cells expressed SA-β-gal and flow cytometric analysis demonstrated that the proportion of cells in the G2/M phase increased.We observed a significant inhibition in cellular proliferation in cells infected with lentivirus or EGCG compared with control treated.


Regulatory relationship

Target gene: P21//P16
Official symbol(s): P21//P16
R-AG-Target gene: --//--
Subcategory: Unclear
Target gene experiment: qRT-PCR//CHIP
Target gene description: Depletion of EZH2 elevated the expression of p21 and p16 in SGC-7901 cells. The effect of loss of EZH2 upon induction of p21 and p16 expression was transcriptional, since the transcript of CDKN1A and CDKN2A, which encodes p21 and p16, respectively, was upregulated in SGC-7901 that exhibited increases in p21 and p16 protein levels.

Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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