| Gene name: | GPX3 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | LO2,MIHA |
| Experiment: | SA-β-gal activity assay |
| Description: | The cellular senescence of liver cells was induced using 500 M H2O2 treatment for 1 hour and then the liver cells were cultured with normal medium. Forty eight hours later, we found that recombinant GPx3 protein (rGPx3) significantly suppressed hepatic senescence in LO2 and MIHA cells in a dose dependent manner. |
| Target gene: | CD44//NOX4//SERPINB2 |
| Official symbol(s): | CD44//NOX4//SERPINB2 |
| R-AG-Target gene: | Downregulation//Downregulation//Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | PCR array |
| Target gene description: | 48h after rGPx3 treatment, 4 down-regulated gene candidates (CD44, Nox4, IFNG, SERPINB2) were identified . Three of them (CD44, Nox4, SERPINB2) were significantly up-regulated when cellular senescence was established (after H2O2 treatment), and sharply decreased upon rGPx3 treatment. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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