| Gene name: | NTN4 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | U251MG |
| Gene ID: | 59277 |
| Category: | protein coding |
| Phenotype: | Glioblastoma |
| Experimental category: | L |
| PMID: | 24265816 |
| Experiment: | SA-β-gal activity assay |
| Description: | We then detected the number of senescent cells by using senescence-associated beta-galactosidase assay. We observed that silencing of either NTN4 or ITGB4 significantly induced U251MG cell senescence. Next we explored the effects of exogenous recombinant NTN4 on TMZ induced senescence. NTN4 significantly inhibited U251MG cell senescence induced by TMZ. |
| Target gene: | ITGB4 |
| Official symbol(s): | ITGB4 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | SA-β-gal activity assay |
| Target gene description: | Although NTN4 reduced the senescence rate of wild type or non-targeting control U251MG cells induced by TMZ treatment,NTN4 did not affect ITGB4-silenced U251MG cells.This result indicates that ITGB4 mediates the protective effect of NTN4 on TMZ treated glioblastoma cells. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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