Aging Overview

Aging gene

Gene name: MIR29A
Aging type: Accelerate
Aging characteristic:
Tissue type: Embryo
Cell name: MEF
Gene ID: 407021
Category: ncRNA
Phenotype: Aging
Experimental category: L
PMID: 29967491
Experiment: SA-β-gal activity assay
Description: Increased abundance of miR-29 (represented miR-29a and miR-29c hereinafter) in early passaged cells (PD4) accelerated senescence whereas decreased amounts of miR-29 in late passaged cells (PD8) delayed senescent phenotypes.


Regulatory relationship

Target gene: H4K20ME3
Official symbol(s): H4K20ME3
R-AG-Target gene: Downregulation
Subcategory: Unclear
Target gene experiment: Western blot
Target gene description: Furthermore, forced expression or inhibition of miR-29, by individual transfection of miRNA mimics (M-miR-29) or inhibitors (I-miR-29a and I-miR-29c), resulted in decreased or increased H4K20me3 abundance, respectively. Gain of function of miR-29 via lentiviral infection led to reduced protein levels of Suv4-20h and H4K20me3.

Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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