Gene name: | MIR29A |
Aging type: | Accelerate |
Aging characteristic: |
Tissue type: | Embryo |
Cell name: | MEF |
Experiment: | SA-β-gal activity assay |
Description: | Increased abundance of miR-29 (represented miR-29a and miR-29c hereinafter) in early passaged cells (PD4) accelerated senescence whereas decreased amounts of miR-29 in late passaged cells (PD8) delayed senescent phenotypes. |
Target gene: | H4K20ME3 |
Official symbol(s): | H4K20ME3 |
R-AG-Target gene: | Downregulation |
Subcategory: | Unclear |
Target gene experiment: | Western blot |
Target gene description: | Furthermore, forced expression or inhibition of miR-29, by individual transfection of miRNA mimics (M-miR-29) or inhibitors (I-miR-29a and I-miR-29c), resulted in decreased or increased H4K20me3 abundance, respectively. Gain of function of miR-29 via lentiviral infection led to reduced protein levels of Suv4-20h and H4K20me3. |
Regulatory pathway: | -- |
R-AG-Pathway: | -- |
Pathway experiment: | -- |
Pathway description: | -- |
Annotation:
Loading,please wait...