| Gene name: | DUSP16 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | PLC-PRF-5 |
| Experiment: | SA-β-gal activity assay |
| Description: | Intriguingly, the percentage of SA-β-Gal-positive cells significantly increased upon DUSP16 silencing. |
| Target gene: | RB |
| Official symbol(s): | RB |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot//Knockdown |
| Target gene description: | In PLC/PRF/5 cells, we observed that decreased levels of Cyclin-dependent kinases (CDKs) upon DUSP16 silencing led to reduced phosphorylation of Rb,as well as reduced phosphorylation of Rb upon DUSP16 silencing. |
| Regulatory pathway: | P53 |
| R-AG-Pathway: | -- |
| Official symbol(s): | TP53 |
| Pathway experiment: | Western blot//Knockdown |
| Pathway description: | Upon DUSP16 knockdown, p53 downstream effectors were dramatically up-regulated . we confirmed that p53 phosphorylation was increased upon DUSP16 knockdown. |
Annotation:
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