| Gene name: | TP53 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MCF-7,A549,HCT116 |
| Experiment: | SA-β-gal activity assay//Cell morphological analysis//Cell proliferation assay |
| Description: | Consistent with these observations, we found that overexpression of human p53β increased markers of cellular senescence in a variety of human tumor cell lines (MCF-7, A549, HCT116), including enlarged cell size, decreased cell proliferation, and elevated senescence-associated β-galactosidase (SA-β-gal) activity. |
| Regulatory pathway: | HSMG-1-RPL26-SRSF7 |
| R-AG-Pathway: | -- |
| Official symbol(s): | SMG1-RPL26-SRSF7 |
| Pathway experiment: | SA-β-gal activity assay//Knockdown |
| Pathway description: | Further, modulation of the hSMG-1-RPL26-SRSF7 pathway required for IR-induced p53β alternative splicing also affected cellular senescence markers as well. Knock-down of hSMG-1, which activates this splicing pathway, increased the percentage of SA-βgalactosidase positive cells and knock-down of SRSF7, a positive splicing factor for p53β, suppressed IR-induced SA-β-galactosidase induction. |
Annotation:
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