| Gene name: | CD59 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | ECA-109 |
| Experiment: | Knockdown//SA-β-gal activity assay//Western blot |
| Description: | The results showed that significant cell cycle arrest at the G2/M phase occurred at 12, 24, and 48 h post-irradiation in CD59-deficient cells compared with that in CD59- sufficient cells .We next detected the effect of CD59 expression on the occurrence of senescence at day 6 after ionizing radiation by SA-β-gal staining. The results revealed that CD59 deficiency significantly increased the percentage of senescent Eca109 cells upon irradiation compared with that observed in CD59-sufficient Eca109 cells.The expression levels of the associated signaling molecules p21 and p16 significantly decreased at 72 h after irradiation in both CD59-sufficient and -deficient cells compared with the levels in the corresponding untreated cells, in which CD59-sufficient cells showed a greater decrease in p21 and p16 expression than CD59-deficient cells . |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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