| Gene name: | CTNND1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HCEC |
| Experiment: | Knockdown//Immunostaining//qRT-PCR//SA-β-gal activity assay |
| Description: | In contrast,weekly knockdowns of p120-Kaiso siRNAs from Day 7 maintained the normal HCEC hexagonal morphology and density till Day 49 as reported11 and prohibited nuclear translocation of p16INK4a, expression of senescence markers,and increase of senescent cells during the entire experimental period. |
| Target gene: | P16//BMI1 |
| Official symbol(s): | P16//BMI1 |
| R-AG-Target gene: | --//-- |
| Subcategory: | Unclear |
| Target gene experiment: | Knockdown//qRT-PCR |
| Target gene description: | The same results were held up by Day 42 following weekly knockdown of p120-Kaiso, resulting in unique downregulation of p16INK4a transcript but upregulation of Bmi1 transcript . |
| Regulatory pathway: | JAK2-STAT3//RHOA-ROCK |
| R-AG-Pathway: | --//-- |
| Pathway experiment: | Knockdown//qRT-PCR//Western blot |
| Pathway description: | In contrast, 5 weekly knockdown of p120-Kaiso since Day 7 dramatically activated not only RhoA as reported11 but also promoted a sustained transcript expression of JAK2 and STAT3. |
Annotation:
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