| Gene name: | PEA15 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | Foreskin |
| Cell name: | HDF |
| Experiment: | SA-β-gal activity assay//Western blot//Immunostaining//Knockdown//Cell proliferation assay |
| Description: | Nuclear translocation of pErk1/2 by siPEA-15 was accompanied with significant reductions of senescence markers in HDF old cells; over 10% decrease of SA-β-gal activity, and 50% decrease of p53 and p21WAF1expressions.Furthermore, treatment of old cells with siPEA-15 significantly reduced senescence markers such as PML body formation, and expressions of 53BP1 and H3K9me2,as opposed to no response in young cells;The senescent cells transfected with siPEA-15 showed significant increase of cell proliferation in 2 days as compared with the siControl transfected cells,and the difference was more significant in 4 days after the transfection. |
| Target gene: | PERK1/2 |
| Official symbol(s): | MAPK1 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Knockdown//Immunostaining |
| Target gene description: | Knockdown of PEA-15 by siPEA-15 transfection significantly induced pErk1/2 translocation. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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