| Gene name: | PPARGC1A |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HBMVEC |
| Experiment: | Knockdown//SA-β-gal activity assay//Tube formation assay//Cell counting//Cell migration assay |
| Description: | PGC1α downregulation also induced cellular senescence-associated phenotypes, such as decreased tube formation, cell proliferation, and cell migration and increased SA-β-gal activity,suggesting that PGC1α contributes to endothelial cell senescence by maintaining mitochondrial function.and the overexpression of PGC1α in old cells increased cell proliferation and partially reduced the senescent phenotype as shown by SA-β-gal staining. |
| Target gene: | HDAC1//SIRT1 |
| Official symbol(s): | HDAC1//SIRT1 |
| R-AG-Target gene: | --//-- |
| Subcategory: | Unclear |
| Target gene experiment: | Knockdown//Western blot |
| Target gene description: | Reduction of HDAC1 by transfection of HDAC1 siRNA into cells increased PGC1α acetylation.Sirt1 knockdown also induced PGC1α acetylation. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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