Gene name: | MYC |
Aging type: | Accelerate |
Aging characteristic: |
Tissue type: | -- |
Cell name: | AG00780,AG03141,Fibroblast |
Gene ID: | 4609 |
Category: | protein coding |
Phenotype: | Werner syndrome |
Experimental category: | HL |
PMID: | 12842909 |
Experiment: | SA-β-gal activity assay//Flow cytometry |
Description: | However, within 2–3 passages, ~30%–70% of the WRN–/– cells expressed senescence-associated (SA-) β-galactosidase and lost proliferative capacity. The senescent phenotype in c-myc-transduced WRN–/– cells was also confirmed at the gene expression level by microarray analysis, which demonstrated elevated expression of several genes characteristic of replicative senescence, such as the matrix proteases. WRN–/– cells that were senescent by virtue of MYC overexpression were largely G1-arrested with a small G2 fraction (data not shown). |
Target gene: | WRN |
Official symbol(s): | WRN |
R-AG-Target gene: | Upregulation |
Subcategory: | Unclear |
Target gene experiment: | Flow cytometry |
Target gene description: | We propose that WRN up-regulation by MYC may promote MYC-driven tumorigenesis by preventing cellular senescence. WRN–/– cells that were senescent by virtue of MYC overexpression were largely G1-arrested with a small G2 fraction (data not shown). |
Regulatory pathway: | -- |
R-AG-Pathway: | -- |
Pathway experiment: | -- |
Pathway description: | -- |
Annotation:
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