Aging Overview

Aging gene

Gene name: MYC
Aging type: Accelerate
Aging characteristic:
Tissue type: --
Cell name: AG00780,AG03141,Fibroblast
Gene ID: 4609
Category: protein coding
Phenotype: Werner syndrome
Experimental category: HL
PMID: 12842909
Experiment: SA-β-gal activity assay//Flow cytometry
Description: However, within 2–3 passages, ~30%–70% of the WRN–/– cells expressed senescence-associated (SA-) β-galactosidase and lost proliferative capacity. The senescent phenotype in c-myc-transduced WRN–/– cells was also confirmed at the gene expression level by microarray analysis, which demonstrated elevated expression of several genes characteristic of replicative senescence, such as the matrix proteases. WRN–/– cells that were senescent by virtue of MYC overexpression were largely G1-arrested with a small G2 fraction (data not shown).


Regulatory relationship

Target gene: WRN
Official symbol(s): WRN
R-AG-Target gene: Upregulation
Subcategory: Unclear
Target gene experiment: Flow cytometry
Target gene description: We propose that WRN up-regulation by MYC may promote MYC-driven tumorigenesis by preventing cellular senescence. WRN–/– cells that were senescent by virtue of MYC overexpression were largely G1-arrested with a small G2 fraction (data not shown).

Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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