| Gene name: | FLT1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HUVEC |
| Gene ID: | 2321 |
| Category: | protein coding |
| Phenotype: | Alzheimer's disease |
| Experimental category: | L |
| PMID: | 30576228 |
| Experiment: | SA-β-Gal activity assay//Western blot |
| Description: | We show that overexpression of chimeric EGLT-VEGFR-1 in HUVECs for 72 h resulted in robust induction of the senescent phenotype as measured by β-galactosidase staining, with or without stimulation with EGF. |
| Regulatory pathway: | P21-P53 |
| R-AG-Pathway: | Activation |
| Official symbol(s): | CDKN1A-TP53 |
| Pathway experiment: | Western blot//qRT-PCR |
| Pathway description: | Western blotting analysis from chimeric receptor EGLT-transfected lysates confirmed the increased expression of the VEGFR-1 protein and increased p21 proteins levels.qRT-PCR analysis showed increased mRNA levels of VEGFR-1, p21, and p53. |
Annotation:
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