| Gene name: | NHEJ1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | Blood |
| Cell name: | CD34+,293T |
| Experiment: | Knockdown//Telomere length assay//Cell proliferation assay//qRT-PCR |
| Description: | shNHEJ1.2/ CD34t transduced cells showed an inhibition of growth compared with scramble infected cells, as previously observed in 293T cells. These cells also showed increased expression of p21 (CDKN1A) 3-fold in relation with control cells and telomerase activity was reduced by 30%.Expression of several telomerase genes was also inhibited, mainly TERT (40%), TERC (20%), and also the expression of some of the shelterin genes and shelterinassociated factors: TERF1 (40%), TERF2 (20%) and TINF2 (20%) and also CTC1 (25%) and RTEL (30%). |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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