| Gene name: | SMC5 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | SUSM1 |
| Experiment: | Knockdown//SA-β-gal activity assay//Cell morphological analysis//Western blot |
| Description: | Knockdown of the SMC5/6 complex in SUSM1 AL T cells caused a progressive increase in the number of SA–β-gal–positive cells over time.This increase correlated with the substantial decrease in telomere lengths in these cells.AL T cells treated with SMC5/6-specific RNAi showed other expected senescence phenotypes, such as morphological changes and an upregulation of the cyclin-dependent kinase inhibitor p21. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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