| Gene name: | MAP3K7 |
| Aging type: | Accelerate |
| Aging characteristic: | Others |
| Tissue type: | -- |
| Cell name: | IMR-90,MRC-5,GP293 |
| Experiment: | qRT-PCR//Colony formation assay |
| Description: | A total of 33 kinases showed pro-senescence effects (particularly MAP3K7, PRKCD, and MATK). |
| Regulatory pathway: | NF-κB |
| R-AG-Pathway: | Activation |
| Official symbol(s): | NFKB1 |
| Pathway experiment: | Luciferase reporter assay |
| Pathway description: | Kinases with strong pro-senescence effects, induced expression of SASP-component genes (IL1A, IL1B, IL6 and IL8) through activation of an NF-kappaB-dependent transcriptional program.The luciferase activity was strongly induced by the 3 kinases indicating that these prosenescent kinases activate the NF-κB pathway. |
Annotation:
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