AgingReG
  1. Search result detail

Aging Overview

Aging gene

Gene name: MAP2K7
Aging type: Prevent
Aging characteristic:
Tissue type: --
Cell name: MCF-7
Gene ID: 5609
Category: protein coding
Phenotype: Breast cancer
Experimental category: HL
PMID: 29768207
Experiment: SA-β-gal activity assay
Description: Upon treatment with inhibitors of MEK, or its downstream effector ERK, senescence was induced to the same degree as in replication stress response competent cells, suggesting MEK pathway inhibition effectively recovered the ability of cells to undergo oncogene-induced senescence.

Regulatory relationship

Regulatory pathway: MDM2-P21
R-AG-Pathway: --
Official symbol(s): MDM2-CDKN1A
Pathway experiment: Western blot
Pathway description: This result was confirmed by western blot analysis, where ERK inhibition blocked MDM2 phosphorylation and increased p21 levels.

Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.


Pathway view

AKT phosphorylates targets in the cytosolAndrogenReceptorATM pathwayATR signaling pathwayAurora A signalingConstitutive Signaling by AKT1 E17K in CancerDirect p53 effectorsErbB4 signaling eventsFSHGlucocorticoid receptor regulatory networkInsulin/IGF pathway-protein kinase B signaling cascadeOncogene Induced SenescenceOxidative Stress Induced Senescencep53 pathwayp53 pathwayP53 pathway feedback loops 1p73 transcription factor networkRegulation of Androgen receptor activityRegulation of retinoblastoma proteinRegulation of TP53 Activity through MethylationRegulation of TP53 Activity through PhosphorylationRegulation of TP53 DegradationStabilization of p53Sumoylation by RanBP2 regulates transcriptional repressionSUMOylation of transcription factorsTrafficking of AMPA receptorsTryptophan degradation ( Tryptophan degradation ) Ubiquitin proteasome pathwayValidated transcriptional targets of deltaNp63 isoformsValidated transcriptional targets of TAp63 isoformsCell cyclep53 signaling pathwayEndocytosisPathways in cancerGliomaProstate cancerMelanomaBladder cancerChronic myeloid leukemiaHs_Cell_Cycle_WP179_89516Hs_ErbB_Signaling_Pathway_WP673_91869Hs_DNA_Damage_Response_(only_ATM_dependent)_WP710_79974Hs_TP53_Network_WP1742_71700Hs_DNA_Damage_Response_WP707_82937Hs_Apoptosis_WP254_88977Hs_Senescence_and_Autophagy_in_Cancer_WP615_81193Hs_Copper_homeostasis_WP3286_89205Hs_Bladder_Cancer_WP2828_89143Hs_Signaling_Pathways_in_Glioblastoma_WP2261_89520Hs_Retinoblastoma_(RB)_in_Cancer_WP2446_87639Hs_Androgen_receptor_signaling_pathway_WP138_79958
AKT phosphorylates targets in the cytosolAngiopoietin receptor Tie2-mediated signalingC-MYB transcription factor networkCi/Gli processing signaling ( Hedgehog signaling pathway ) Class I PI3K signaling events mediated by AktConstitutive Signaling by AKT1 E17K in CancerCyclin A:Cdk2-associated events at S phase entryCyclin D associated events in G1Cyclin E associated events during G1/S transitionDirect p53 effectorsDNA Damage/Telomere Stress Induced SenescenceE2F transcription factor networkFormation of Senescence-Associated Heterochromatin Foci (SAHF)Gli processing signaling ( Hedgehog signaling pathway ) Glucocorticoid receptor regulatory networkInterleukin signaling pathwayNotch signaling pathwayOrc1 removal from chromatinp53-Dependent G1 DNA Damage Responsep53 pathwayp53 pathway feedback loops 2p73 transcription factor networkRegulation of nuclear SMAD2/3 signalingRegulation of retinoblastoma proteinSCF(Skp2)-mediated degradation of p27/p21Senescence-Associated Secretory Phenotype (SASP)Signaling events mediated by HDAC Class IIISignaling events mediated by PRLTGF_beta_ReceptorThe role of GTSE1 in G2/M progression after G2 checkpointTP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestValidated targets of C-MYC transcriptional repressionValidated transcriptional targets of TAp63 isoformsVinblastine Action PathwayVincristine Action PathwayVindesine Action PathwayVinorelbine Action PathwayErbB signaling pathwayCell cyclep53 signaling pathwayHepatitis CPathways in cancerGliomaProstate cancerMelanomaBladder cancerChronic myeloid leukemiaHs_Cell_Cycle_WP179_89516Hs_ErbB_Signaling_Pathway_WP673_91869Hs_DNA_Damage_Response_(only_ATM_dependent)_WP710_79974Hs_DNA_Damage_Response_WP707_82937Hs_miRNA_Regulation_of_DNA_Damage_Response_WP1530_84694Hs_Apoptosis-related_network_due_to_altered_Notch3_in_ovarian_cancer_WP2864_79278Hs_miRNAs_involved_in_DNA_damage_response_WP1545_84697Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640Hs_Senescence_and_Autophagy_in_Cancer_WP615_81193Hs_Integrated_Cancer_Pathway_WP1971_82939Hs_ATM_Signaling_Pathway_WP2516_90247Hs_LncRNA-mediated_mechanisms_of_therapeutic_resistance_WP3672_87395Hs_Signaling_Pathways_in_Glioblastoma_WP2261_89520Hs_AMP-activated_Protein_Kinase_(AMPK)_Signaling_WP1403_90259Hs_Aryl_Hydrocarbon_Receptor_WP2586_91687Hs_Retinoblastoma_(RB)_in_Cancer_WP2446_87639Hs_TGF-beta_Signaling_Pathway_WP366_90028Hs_Androgen_receptor_signaling_pathway_WP138_79958
About risk SNP and eQTL

Loading,please wait...

Data source of:
Expression of gene(s)
Cell line (ENCODE) Primary cell (ENCODE) Normal tissue (GTEx) Cell line (CCLE)