| Gene name: | GDF15 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | TBE |
| Experiment: | SA-β-gal activity assay |
| Description: | Disruption of GDF15 markedly reduced CSEinduced cellular senescence, represented by less induced SA β-gal activity, less inhibition of cell proliferation, and less HMGB1 release. |
| Regulatory pathway: | ALK1-SMAD1 |
| R-AG-Pathway: | Activation |
| Official symbol(s): | ALK-SMAD1 |
| Pathway experiment: | Western blot |
| Pathway description: | GDF15 protein time-dependently induced phosphorylation of Smad1/5/8 in primary human airway epithelial cells. Moreover, a direct binding assay of GDF15 and ALK1 protein was performed in vitro to confirm the direct interaction between GDF15 and ALK1. We found that GDF15 bound to the ALK1 receptor in a dose-dependent manner.In our pilot study, CSE significantly increased GDF15, HMGB1, p21 and Smad1/5/8 phosphorylation at day 1 in hTBE cells. |
Annotation:
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