| Gene name: | SIRT1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | VSMC |
| Gene ID: | 23411 |
| Category: | protein coding |
| Phenotype: | Abdominal aortic aneurysms |
| Experimental category: | HL |
| PMID: | 27650558 |
| Experiment: | SA-β-gal activity assay |
| Description: | As expected, the SA-β-gal activity assay also confirmed the antiaging effect of SIRT1 overexpression. |
| Target gene: | P21 |
| Official symbol(s): | P21 |
| R-AG-Target gene: | Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | SA-β-gal activity assay//Western blot//Knockdown |
| Target gene description: | These results suggest that SIRT1 inhibited Ang II–induced p21 expression by deacetylation of p53 in AAAs. The increased p21 expression caused by Ang II was significantly greater in the aortas of aged mice than that in young mice. Similarly, increased p21 expression was found in human AAA samples.The results of SA-β-gal staining indicated that p21 knock-down not only blocked Ang II–induced VSMC senescence but also eradicated the promotional effect of SIRT1 knockout. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
Loading,please wait...