Aging Overview

Aging gene

Gene name: IL1B
Aging type: Accelerate
Aging characteristic:
Tissue type: --
Cell name: HUVEC
Gene ID: 3553
Category: protein coding
Phenotype: Aging
Experimental category: L
PMID: 28064010
Experiment: SA-β-gal activity assay//Western blot
Description: To address this, primary HUVECs were treated with recombinant human IL-1β for 6 days, the cell senescence was confirmed by SA-β-galactosidase activity.Furthermore, protein expression levels of senescence markers, such as p53 and p21, were also significantly upregulated in a time dependent way after IL-1β treatment with peak values of 2.8 fold and 3.1fold respectively.


Regulatory relationship

Target gene: CASPASE-1//NLRP3
Official symbol(s): CASPASE-1//NLRP3
R-AG-Target gene: --//--
Subcategory: Unclear
Target gene experiment: Western blot
Target gene description: Interestingly, in the presence of z-YVAD-fmk, a caspase-1 inhibitor, mature IL-1 processing was abolished in senescent HUVECs but pro-IL-1 expression remained unchanged .SiNLRP3 or siASC transfection in the cells could significantly decrease their protein expression induced by bleomycin. As expected, IL-1 productions were also strongly attenuated in these silent senescent cells, but there was no significant effect in pro-IL-1 expression.

Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

Loading,please wait...