| Gene name: | ALOX15B |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | Prostate |
| Cell name: | -- |
| Gene ID: | 247 |
| Category: | protein coding |
| Phenotype: | Prostate cancer |
| Experimental category: | L |
| PMID: | 24732589 |
| Experiment: | SA-β-gal activity assay |
| Description: | There was a noticeable increase in SA-βgal-positive glands in fl26 prostates compared with WT prostates, as previously observed.18 Important, there were also significantly more SA-βgal-positive glands in the prostates of Myc;LOX animals compared with Hi-Myc mouse prostates. |
| Target gene: | P27//RB//RB1CC1 |
| Official symbol(s): | P27//RB//RB1CC1 |
| R-AG-Target gene: | --// --// -- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | Together, the results on p27 and Rb suggest that 15-LOX2-mediated tumor suppression in Hi-Myc model might involve cell senescence induction associated with molecular changes in these 2 molecules.The fact that increased Rb1cc1 expression was observed in 15-LOX2fl26 animals, which produce enzymatically Activate 15-LOX2 but not in WT or in 15-LOX2svb, which is enzymatically inActivate,18 suggests that 15-LOX2 metabolites may be mediating the Rb1cc1 induction. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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