Sample overview of MDA-MB-468

Sample ID: Sample_02_095
Biosample type: Cell line
Tissue type: Mammary Gland
Biosample name: MDA-MB-468
Data source: NCBI GEO/SRA
GSE ID: GSE65201
Cancer type: basal-like breast cancer
CRC number: 2570
TF number of all CRCs: 48
TF list of all CRCs: SOX9, ELF3, RREB1, SP2, EHF, IRF1, FOXC1, RUNX1, BHLHE40, RARA, JUND, ZBTB7B, TGIF1, SREBF1, MAFF, IRF2, MYC, SPDEF, JUNB, MAFK, TFAP2C, IRX3, RUNX2, TFAP2A, IRX5, GRHL1, PBX1, NFATC4, EN1, MYCN, NFIB, HES1, FOXI1, SOX4, NFIX, FOXA1, BCL6, TFCP2L1, CREB3L2, FOSL2, TEAD3, BARX2, NR2F6, ZNF217, HIF1A, ARID5B, E2F2, IRX6

The most representative CRC of MDA-MB-468
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Relationship plot of CRC model
TF number of this CRC: 22
CRC socre: 1873.955
TF list of the most representative CRC
TF name TF family Frequency of TFs
BHLHE40 bHLH 2295 / 2570
EHF ETS 2570 / 2570
ELF3 ETS 2570 / 2570
EN1 Homeobox 1030 / 2570
FOXC1 Fork_head 2570 / 2570
HES1 bHLH 998 / 2570
IRF1 IRF 2570 / 2570
JUNB TF_bZIP 1422 / 2570
JUND TF_bZIP 2089 / 2570
MAFK TF_bZIP 1352 / 2570
NFIB CTF/NFI 1003 / 2570
RARA THR-like 2093 / 2570
RREB1 zf-C2H2 2570 / 2570
RUNX1 Runt 2467 / 2570
SOX9 HMG 2570 / 2570
SP2 zf-C2H2 2570 / 2570
SPDEF ETS 1504 / 2570
SREBF1 bHLH 1602 / 2570
TEAD3 TEA 406 / 2570
TFAP2C AP-2 1283 / 2570
TGIF1 Homeobox 1716 / 2570
ZBTB7B ZBTB 1977 / 2570

All CRCs of MDA-MB-468
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CRC rank TF list of CRCs CRC score TF number of CRC Detail of CRC

Frequency of TFs that appear in CRCs
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TF name Frequency of TFs TF family Ensembl ID
RREB1 2570 / 2570 zf-C2H2 ENSG00000124782
SOX9 2570 / 2570 HMG ENSG00000125398
EHF 2570 / 2570 ETS ENSG00000135373
SP2 2570 / 2570 zf-C2H2 ENSG00000167182
ELF3 2570 / 2570 ETS ENSG00000163435
FOXC1 2570 / 2570 Fork_head ENSG00000054598
IRF1 2570 / 2570 IRF ENSG00000125347
RUNX1 2467 / 2570 Runt ENSG00000159216
BHLHE40 2295 / 2570 bHLH ENSG00000134107
RARA 2093 / 2570 THR-like ENSG00000131759
JUND 2089 / 2570 TF_bZIP ENSG00000130522
ZBTB7B 1977 / 2570 ZBTB ENSG00000160685
TGIF1 1716 / 2570 Homeobox ENSG00000177426
SREBF1 1602 / 2570 bHLH ENSG00000072310
MAFF 1596 / 2570 TF_bZIP ENSG00000185022
IRF2 1572 / 2570 IRF ENSG00000168310
MYC 1540 / 2570 bHLH ENSG00000136997
SPDEF 1504 / 2570 ETS ENSG00000124664
JUNB 1422 / 2570 TF_bZIP ENSG00000171223
MAFK 1352 / 2570 TF_bZIP ENSG00000198517
TFAP2C 1283 / 2570 AP-2 ENSG00000087510
IRX3 1227 / 2570 Homeobox ENSG00000177508
RUNX2 1182 / 2570 Runt ENSG00000124813
TFAP2A 1175 / 2570 AP-2 ENSG00000137203
IRX5 1160 / 2570 Homeobox ENSG00000176842
GRHL1 1154 / 2570 CP2 ENSG00000134317
PBX1 1101 / 2570 Homeobox ENSG00000185630
NFATC4 1066 / 2570 RHD ENSG00000100968
EN1 1030 / 2570 Homeobox ENSG00000163064
MYCN 1025 / 2570 bHLH ENSG00000134323
NFIB 1003 / 2570 CTF/NFI ENSG00000147862
HES1 998 / 2570 bHLH ENSG00000114315
FOXI1 890 / 2570 Fork_head ENSG00000168269
SOX4 873 / 2570 HMG ENSG00000124766
NFIX 856 / 2570 CTF/NFI ENSG00000008441
FOXA1 822 / 2570 Fork_head ENSG00000129514
BCL6 707 / 2570 ZBTB ENSG00000113916
TFCP2L1 636 / 2570 CP2 ENSG00000115112
CREB3L2 489 / 2570 TF_bZIP ENSG00000182158
FOSL2 460 / 2570 TF_bZIP ENSG00000075426
TEAD3 406 / 2570 TEA ENSG00000007866
BARX2 307 / 2570 Homeobox ENSG00000043039
NR2F6 230 / 2570 RXR-like ENSG00000160113
ZNF217 211 / 2570 zf-C2H2 ENSG00000171940
HIF1A 170 / 2570 Others ENSG00000100644
ARID5B 132 / 2570 ARID ENSG00000150347
E2F2 103 / 2570 E2F ENSG00000007968
IRX6 64 / 2570 Homeobox ENSG00000159387

Indegree and outdegree of TFs
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TF name Indegree Outdegree Node connections
ZNF217 51 47 98
NR2F6 41 61 102
NFATC4 49 59 108
FOXA1 47 60 107
JUNB 49 58 107
JUND 48 61 109
MYCN 48 58 106
FOXI1 46 61 107
SOX9 51 62 113
TEAD3 41 62 103
ELF3 51 62 113
RREB1 51 63 114
MAFF 50 56 106
RARA 49 62 111
CREB3L2 50 54 104
RUNX1 50 63 113
GRHL1 48 57 105
TFAP2A 49 63 112
TFAP2C 47 63 110
NFIX 51 56 107
EN1 48 60 108
SOX4 45 61 106
FOSL2 46 55 101
IRX5 49 57 106
IRX6 37 52 89
SP2 51 63 114
IRX3 51 55 106
ZBTB7B 48 60 108
TFCP2L1 50 53 103
EHF 51 62 113
HIF1A 48 44 92
MYC 51 60 111
PBX1 50 56 106
IRF2 49 61 110
IRF1 51 62 113
BARX2 51 45 96
E2F2 40 58 98
ARID5B 49 46 95
SPDEF 50 63 113
NFIB 48 57 105
RUNX2 48 58 106
BHLHE40 50 62 112
SREBF1 49 60 109
MAFK 47 62 109
FOXC1 51 62 113
HES1 49 55 104
BCL6 47 63 110
TGIF1 51 58 109

Expression of TFs in all CRCs