Cancer CRCdb

TF information

TF name:	SPDEF
TF family:	ETS
Ensembl gene ID:	ENSG00000124664
Ensembl protein ID:	ENSP00000363149, ENSP00000442715
Entrez gene ID:	25803

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of SPDEF in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_022	Cell line	Prostate	C4-2B	0.83333333333333
Sample_01_068	Cell line	Prostate: derived from metastatic site: vertebral metastasis	VCaP	0.87671232876712
Sample_02_079	Cell line	Mammary Gland	T-47D_1	1
Sample_02_095	Cell line	Mammary Gland	MDA-MB-468	0.5852140077821
Sample_02_096	Cell line	Mammary Gland	ZR-75-1_1	0.90217391304348
Sample_02_394	Cell line	Mammary Gland	T-47D_2	0.46153846153846
Sample_02_403	Cell line	Mammary Gland	T-47D_untreat	1
Sample_02_404	Cell line	Mammary Gland	ZR-75-1_2	1

SPDEF distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_01_022	Prostate	Cell line	C4-2B
Sample_01_068	Prostate: derived from metastatic site: vertebral metastasis	Cell line	VCaP
Sample_02_079	Mammary Gland	Cell line	T-47D_1
Sample_02_095	Mammary Gland	Cell line	MDA-MB-468
Sample_02_096	Mammary Gland	Cell line	ZR-75-1_1
Sample_02_394	Mammary Gland	Cell line	T-47D_2
Sample_02_403	Mammary Gland	Cell line	T-47D_untreat
Sample_02_404	Mammary Gland	Cell line	ZR-75-1_2

SPDEF distribution in all CRCs

Genomic distribution of SEs associated with SPDEF

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Mutation of SPDEF

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of SPDEF

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
rs766462365	chr6	34508841	34508841	G	A	exonic	SPDEF	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr6	34506142	34506142	C	A	exonic	SPDEF	nonsynonymous	HNSC\|1\|512\|0.00195
rs200724717	chr6	34512202	34512202	C	T	exonic	SPDEF	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs747037762	chr6	34512084	34512084	G	A	exonic	SPDEF	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr6	34507072	34507072	G	A	exonic	SPDEF	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	34512036	34512036	A	G	exonic	SPDEF	nonsynonymous	HNSC\|1\|512\|0.00195
rs748202781	chr6	34511927	34511927	C	T	exonic	SPDEF	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,DLBC\|1\|48\|0.02083
rs770126986	chr6	34512014	34512014	C	T	exonic	SPDEF	stopgain	HNSC\|1\|512\|0.00195
-	chr6	34512076	34512076	G	T	exonic	SPDEF	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
rs755931546	chr6	34512079	34512079	C	T	exonic	SPDEF	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr6	34506127	34506127	T	C	exonic	SPDEF	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr6	34512051	34512051	G	A	exonic	SPDEF	nonsynonymous	SKCM\|1\|368\|0.00272
rs369097952	chr6	34512112	34512112	G	A	exonic	SPDEF	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs576498823	chr6	34512080	34512080	G	A	exonic	SPDEF	synonymous	CESC\|1\|194\|0.00515
-	chr6	34512185	34512185	G	C	exonic	SPDEF	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs375427681	chr6	34512160	34512160	G	A	exonic	SPDEF	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,HNSC\|1\|512\|0.00195
-	chr6	34508912	34508912	C	T	exonic	SPDEF	stopgain	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	34507087	34507087	C	T	exonic	SPDEF	nonsynonymous	SKCM\|1\|368\|0.00272
rs374206315	chr6	34507169	34507169	C	G	exonic	SPDEF	synonymous	CESC\|1\|194\|0.00515
-	chr6	34508917	34508917	G	A	exonic	SPDEF	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	34511828	34511828	C	A	exonic	SPDEF	nonsynonymous	UCEC\|1\|248\|0.00403
rs772048340	chr6	34511928	34511928	G	A	exonic	SPDEF	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs200344679	chr6	34507170	34507170	G	A	exonic	SPDEF	nonsynonymous	HNSC\|2\|512\|0.00391
-	chr6	34511828	34511828	C	T	exonic	SPDEF	synonymous	SKCM\|1\|368\|0.00272
rs758658860	chr6	34512083	34512083	C	T	exonic	SPDEF	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	34512224	34512224	G	A	exonic	SPDEF	synonymous	OV\|1\|469\|0.00213
rs752209770	chr6	34511903	34511903	G	A	exonic	SPDEF	synonymous	UCEC\|1\|248\|0.00403
-	chr6	34507062	34507062	T	C	exonic	SPDEF	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr6	34512099	34512099	G	T	exonic	SPDEF	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs143867487	chr6	34512141	34512141	G	A	exonic	SPDEF	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	34512073	34512073	C	T	exonic	SPDEF	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	34508852	34508852	C	T	exonic	SPDEF	synonymous	LAML\|1\|197\|0.00508,SKCM\|1\|368\|0.00272
rs148079586	chr6	34506194	34506194	G	A	exonic	SPDEF	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr6	34511953	34511953	G	A	exonic	SPDEF	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr6	34506121	34506121	T	C	exonic	SPDEF	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr6	34507088	34507088	C	T	exonic	SPDEF	synonymous	SKCM\|1\|368\|0.00272
-	chr6	34507128	34507128	G	A	exonic	SPDEF	nonsynonymous	HNSC\|2\|512\|0.00391
rs760577698	chr6	34512119	34512119	G	A	exonic	SPDEF	synonymous	SKCM\|1\|368\|0.00272
-	chr6	34511861	34511861	G	A	exonic	SPDEF	synonymous	SKCM\|1\|368\|0.00272
rs776586725	chr6	34506131	34506131	G	A	exonic	SPDEF	nonsynonymous	BRCA\|1\|982\|0.00102
rs2233638	chr6	34512065	34512065	G	A	exonic	SPDEF	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	34508830	34508830	C	A	exonic	SPDEF	stopgain	LUSC\|1\|178\|0.00562
-	chr6	34508954	34508954	G	T	exonic	SPDEF	synonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr6	34506078	34506078	G	A	exonic	SPDEF	synonymous	LUAD\|1\|543\|0.00184
-	chr6	34511872	34511872	G	T	exonic	SPDEF	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	34508955	34508955	G	C	exonic	SPDEF	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr6	34511922	34511922	C	T	exonic	SPDEF	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	34511907	34511907	G	T	exonic	SPDEF	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	34511883	34511883	T	C	exonic	SPDEF	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	34512173	34512173	G	-	exonic	SPDEF	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	34512074	34512074	C	A	exonic	SPDEF	nonsynonymous	LUAD\|1\|543\|0.00184
rs374584207	chr6	34507305	34507305	C	T	exonic	SPDEF	synonymous	DLBC\|1\|48\|0.02083
-	chr6	34507171	34507171	A	G	exonic	SPDEF	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs145642998	chr6	34506164	34506164	C	T	exonic	SPDEF	nonsynonymous	PRAD\|1\|499\|0.00200
rs774173485	chr6	34508834	34508834	C	T	exonic	SPDEF	synonymous	SKCM\|1\|368\|0.00272
-	chr6	34508806	34508806	G	A	exonic	SPDEF	synonymous	LUAD\|1\|543\|0.00184
-	chr6	34511944	34511944	C	G	exonic	SPDEF	nonsynonymous	BRCA\|1\|982\|0.00102
rs146713427	chr6	34511830	34511830	C	T	exonic	SPDEF	nonsynonymous	SKCM\|1\|368\|0.00272

Disease information of SPDEF

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
SPDEF	ovarian neoplasm	C04;C13;C19	Neoplastic Process	CTD_human
SPDEF	Malignant neoplasm of ovary	C04;C13;C19	Neoplastic Process	CTD_human

Pathway associated with SPDEF

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number

Go term information of SPDEF

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GO_term_name	GO_term_type	TF_name
GO_LUNG_EPITHELIUM_DEVELOPMENT	BP	SPDEF
GO_POSITIVE_REGULATION_OF_CELL_FATE_COMMITMENT	BP	SPDEF
GO_EPITHELIAL_CELL_DEVELOPMENT	BP	SPDEF
GO_LUNG_CELL_DIFFERENTIATION	BP	SPDEF
GO_INTESTINAL_EPITHELIAL_CELL_DEVELOPMENT	BP	SPDEF
GO_INTESTINAL_EPITHELIAL_CELL_DIFFERENTIATION	BP	SPDEF
GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DEVELOPMENT	BP	SPDEF
GO_REGULATION_OF_CELL_FATE_COMMITMENT	BP	SPDEF
GO_GLANDULAR_EPITHELIAL_CELL_DIFFERENTIATION	BP	SPDEF

Survival analysis of SPDEF

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of SPDEF

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)