Cancer CRCdb

TF information

TF name:	SREBF1
TF family:	bHLH
Ensembl gene ID:	ENSG00000072310
Ensembl protein ID:	ENSP00000411516, ENSP00000379100, ENSP00000379106, ENSP00000261646, ENSP00000348069
Entrez gene ID:	6720

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of SREBF1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_022	Cell line	Prostate	C4-2B	0.52380952380952
Sample_01_059	Cell line	Lung	PC-9	0.53333333333333
Sample_02_007	Other	Cervical	cervical-cancer_vector	0.16556291390728
Sample_02_021	Cell line	Colon	V429	0.38253098875757
Sample_02_095	Cell line	Mammary Gland	MDA-MB-468	0.62334630350195
Sample_02_096	Cell line	Mammary Gland	ZR-75-1_1	1
Sample_02_114	Cell line	Mammary Gland	CAL51	0.39195979899497
Sample_02_115	Cell line	Mammary Gland	MCF-7	0.6
Sample_02_164	Cell line	Lung	H2087_Parental	0.36666666666667
Sample_02_166	Cell line	Mammary Gland	HCC1954_Parental	0.388
Sample_02_168	Cell line	Prostate	LNCaP	0.49809885931559
Sample_02_180	Cell line	Human melanoma	CJM	0.3046875
Sample_02_181	Cell line	Human melanoma	COLO679	0.37546666666667
Sample_02_182	Cell line	Human melanoma	LOX-IMVI	0.34195402298851
Sample_02_184	Cell line	Skin	SKMEL30	0.067524115755627
Sample_02_192	Cell line	Stomach	MKN45	0.33333333333333
Sample_02_204	Cell line	Stomach	IM95	0.5
Sample_02_208	Cell line	Stomach	YCC3	0.375
Sample_02_219	Cell line	Mammary Gland	MDA-MB-231	1
Sample_02_228	Cell line	Oesophagus	KYSE510	0.36346691519105
Sample_02_236	Cell line	Colon	V206	0.80745341614907
Sample_02_237	Cell line	Colon	V389	0.52733296521259
Sample_02_241	Cell line	Colon	V456	0.48532731376975
Sample_02_242	Cell line	Colon	V481	0.41161956034096
Sample_02_250	Tissue	Brain	tumormodel3691	1
Sample_02_258	Other	Lung	NCI-H1299_EGFP-NEO_reporter_cells_DMSO	0.33333333333333
Sample_02_267	Cell line	Kidney	786-O	0.8
Sample_02_268	Cell line	Kidney	A-498	0.49824626176851
Sample_02_280	Cell line	Mammary Gland	SUM159_DMSO_24h	0.75
Sample_02_285	Cell line	Liver	HuH7_untreat	0.21254355400697
Sample_02_300	Cell line	Neuroblastoma	CLB-PE	0.20512820512821
Sample_02_304	Cell line	Neuroblastoma	N206	0.51086956521739
Sample_02_316	Cell line	Neuroblastoma	CHP212	0.31868131868132
Sample_02_322	Cell line	Colon	Caco-2	0.28532974427995
Sample_02_323	Cell line	Colon	RKO	0.9
Sample_02_354	Cell line	Colon	Colo205	0.97747747747748
Sample_02_355	Cell line	Colon	HCT15	0.79761904761905
Sample_02_356	Cell line	Colon	Sw480	0.34838709677419
Sample_02_357	Cell line	Colon	Colo320	1
Sample_02_358	Cell line	Colon	LS180	0.27646129541864
Sample_02_359	Cell line	Colon	Colo741	0.34939759036145
Sample_02_395	Cell line	Mammary Gland	BT-549	0.2951048951049
Sample_02_404	Cell line	Mammary Gland	ZR-75-1_2	0.56834532374101
Sample_02_406	Cell line	Mammary Gland	ZR-75-30_parental	0.17391304347826
Sample_02_424	Cell line	Colon	SW620	0.3768115942029

SREBF1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_01_022	Prostate	Cell line	C4-2B
Sample_01_059	Lung	Cell line	PC-9
Sample_02_095	Mammary Gland	Cell line	MDA-MB-468
Sample_02_096	Mammary Gland	Cell line	ZR-75-1_1
Sample_02_181	Human melanoma	Cell line	COLO679
Sample_02_204	Stomach	Cell line	IM95
Sample_02_219	Mammary Gland	Cell line	MDA-MB-231
Sample_02_236	Colon	Cell line	V206
Sample_02_237	Colon	Cell line	V389
Sample_02_241	Colon	Cell line	V456
Sample_02_250	Brain	Tissue	tumormodel3691
Sample_02_267	Kidney	Cell line	786-O
Sample_02_268	Kidney	Cell line	A-498
Sample_02_280	Mammary Gland	Cell line	SUM159_DMSO_24h
Sample_02_304	Neuroblastoma	Cell line	N206
Sample_02_323	Colon	Cell line	RKO
Sample_02_354	Colon	Cell line	Colo205
Sample_02_355	Colon	Cell line	HCT15
Sample_02_357	Colon	Cell line	Colo320
Sample_02_404	Mammary Gland	Cell line	ZR-75-1_2
Sample_02_406	Mammary Gland	Cell line	ZR-75-30_parental

SREBF1 distribution in all CRCs

Genomic distribution of SEs associated with SREBF1

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Mutation of SREBF1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of SREBF1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr17	17720296	17720296	-	T	exonic	SREBF1	frameshift	HNSC\|1\|512\|0.00195
-	chr17	17718151	17718152	GT	-	exonic	SREBF1	frameshift	PCPG\|1\|184\|0.00543
rs375059574	chr17	17723594	17723594	C	T	exonic	SREBF1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs529689353	chr17	17719281	17719281	G	T	exonic	SREBF1	nonsynonymous	SARC\|1\|247\|0.00405
-	chr17	17722357	17722357	G	A	exonic	SREBF1	synonymous	HNSC\|1\|512\|0.00195
rs762042920	chr17	17723585	17723585	G	A	exonic	SREBF1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	17719341	17719341	C	T	exonic	SREBF1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr17	17719529	17719529	A	T	exonic	SREBF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	17719999	17719999	G	T	exonic	SREBF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs773391894	chr17	17723754	17723754	C	T	exonic	SREBF1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
rs754006664	chr17	17721595	17721595	G	A	exonic	SREBF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,THCA\|1\|504\|0.00198
-	chr17	17716923	17716923	A	G	exonic	SREBF1	nonsynonymous	BLCA\|2\|396\|0.00505
-	chr17	17720719	17720719	G	A	exonic	SREBF1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr17	17723610	17723613	GGAG	-	exonic	SREBF1	frameshift	LIHC\|1\|373\|0.00268
-	chr17	17720301	17720301	G	A	exonic	SREBF1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr17	17716049	17716049	T	C	exonic	SREBF1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr17	17726883	17726883	C	A	exonic	SREBF1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr17	17723568	17723568	G	A	exonic	SREBF1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	17722368	17722368	T	C	exonic	SREBF1	nonsynonymous	OV\|1\|469\|0.00213
-	chr17	17722483	17722483	A	G	exonic	SREBF1	synonymous	CHOL\|1\|35\|0.02857
-	chr17	17722719	17722719	G	A	exonic	SREBF1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr17	17720609	17720609	G	-	exonic	SREBF1	frameshift	PCPG\|1\|184\|0.00543
-	chr17	17740047	17740047	T	-	exonic	SREBF1	frameshift	TGCT\|1\|155\|0.00645
rs776609977	chr17	17719808	17719808	G	A	exonic	SREBF1	synonymous	ESCA\|1\|185\|0.00541
-	chr17	17718242	17718242	G	A	exonic	SREBF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	17722433	17722433	C	T	exonic	SREBF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	17726837	17726837	A	T	exonic	SREBF1	nonsynonymous	LUAD\|1\|543\|0.00184
rs775151936	chr17	17722984	17722984	C	T	exonic	SREBF1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs571282377	chr17	17717630	17717630	T	C	exonic	SREBF1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr17	17716904	17716904	G	T	exonic	SREBF1	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr17	17721227	17721227	G	A	exonic	SREBF1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr17	17718605	17718605	G	A	exonic	SREBF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	17723598	17723598	T	C	exonic	SREBF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	17722461	17722461	T	C	exonic	SREBF1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr17	17718569	17718569	G	A	exonic	SREBF1	nonsynonymous	HNSC\|2\|512\|0.00391
-	chr17	17718545	17718545	C	T	exonic	SREBF1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr17	17716752	17716752	G	T	exonic	SREBF1	synonymous	BRCA\|1\|982\|0.00102
-	chr17	17723758	17723758	C	T	exonic	SREBF1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs770190474	chr17	17719659	17719659	G	A	exonic	SREBF1	synonymous	LIHC\|1\|373\|0.00268
rs776419406	chr17	17716950	17716950	C	T	exonic	SREBF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	17721579	17721579	T	C	exonic	SREBF1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr17	17722529	17722529	G	A	exonic	SREBF1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	17721038	17721038	G	T	exonic	SREBF1	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr17	17716712	17716712	T	C	exonic	SREBF1	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr17	17726908	17726908	C	G	exonic	SREBF1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	17718180	17718180	G	A	exonic	SREBF1	synonymous	LUAD\|1\|543\|0.00184
rs746334705	chr17	17721180	17721180	C	T	exonic	SREBF1	nonsynonymous	PRAD\|1\|499\|0.00200,UCEC\|1\|248\|0.00403
-	chr17	17720296	17720296	C	G	exonic	SREBF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	17716753	17716753	G	C	exonic	SREBF1	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr17	17722421	17722421	C	A	exonic	SREBF1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr17	17721617	17721617	G	A	exonic	SREBF1	synonymous	SKCM\|1\|368\|0.00272
-	chr17	17720439	17720439	A	G	exonic	SREBF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	17715992	17715992	C	T	exonic	SREBF1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	17721591	17721591	G	A	exonic	SREBF1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs781337368	chr17	17719990	17719990	G	A	exonic	SREBF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	17719280	17719280	G	A	exonic	SREBF1	synonymous	SKCM\|1\|368\|0.00272
-	chr17	17723577	17723577	G	A	exonic	SREBF1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	17719174	17719174	C	G	exonic	SREBF1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr17	17720655	17720655	C	A	exonic	SREBF1	synonymous	LUAD\|1\|543\|0.00184
-	chr17	17722392	17722392	A	G	exonic	SREBF1	nonsynonymous	SARC\|1\|247\|0.00405
-	chr17	17719328	17719328	G	A	exonic	SREBF1	synonymous	LIHC\|1\|373\|0.00268
-	chr17	17723477	17723477	T	G	exonic	SREBF1	synonymous	PAAD\|1\|185\|0.00541
-	chr17	17719624	17719624	T	-	exonic	SREBF1	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	17723494	17723494	G	A	exonic	SREBF1	synonymous	SKCM\|1\|368\|0.00272
rs765844815	chr17	17719921	17719921	G	A	exonic	SREBF1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	17722350	17722350	G	T	exonic	SREBF1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr17	17720902	17720902	C	A	intronic	SREBF1	unknown	PAAD\|1\|185\|0.00541
-	chr17	17721087	17721087	G	A	exonic	SREBF1	nonsynonymous	SKCM\|1\|368\|0.00272
rs115855236	chr17	17723595	17723595	G	A	exonic	SREBF1	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr17	17719301	17719301	C	G	exonic	SREBF1	nonsynonymous	HNSC\|1\|512\|0.00195
rs566513103	chr17	17722407	17722407	C	T	exonic	SREBF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	17721095	17721095	G	T	exonic	SREBF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	17718011	17718011	G	A	exonic	SREBF1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr17	17716007	17716007	G	C	exonic	SREBF1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr17	17722528	17722528	G	A	exonic	SREBF1	synonymous	SKCM\|1\|368\|0.00272
-	chr17	17716753	17716753	-	C	exonic	SREBF1	frameshift	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr17	17722871	17722871	G	A	exonic	SREBF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	17721600	17721600	C	G	exonic	SREBF1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr17	17723486	17723486	C	A	exonic	SREBF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	17716720	17716720	C	T	exonic	SREBF1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr17	17716089	17716089	-	G	exonic	SREBF1	frameshift	BRCA\|2\|982\|0.00204
rs149599437	chr17	17723649	17723649	G	A	exonic	SREBF1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr17	17721640	17721640	G	C	exonic	SREBF1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr17	17740045	17740045	G	-	exonic	SREBF1	frameshift	TGCT\|1\|155\|0.00645
-	chr17	17720736	17720736	C	T	exonic	SREBF1	synonymous	SKCM\|1\|368\|0.00272
rs529460681	chr17	17718001	17718001	C	T	exonic	SREBF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	17721042	17721042	C	-	exonic	SREBF1	frameshift	LIHC\|1\|373\|0.00268
rs568851975	chr17	17722985	17722985	G	A	exonic	SREBF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	17719285	17719285	G	A	exonic	SREBF1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	17720635	17720635	C	A	exonic	SREBF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs781581475	chr17	17718610	17718610	C	T	exonic	SREBF1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr17	17721094	17721094	G	-	exonic	SREBF1	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	17718043	17718043	T	A	exonic	SREBF1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr17	17716711	17716711	C	A	exonic	SREBF1	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr17	17722964	17722964	G	T	exonic	SREBF1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr17	17718184	17718184	C	T	exonic	SREBF1	nonsynonymous	LUSC\|1\|178\|0.00562
rs781342104	chr17	17720700	17720700	C	T	exonic	SREBF1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	17716991	17716991	C	T	exonic	SREBF1	synonymous	HNSC\|1\|512\|0.00195
rs769850076	chr17	17716744	17716744	G	A	exonic	SREBF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	17719813	17719813	C	T	exonic	SREBF1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr17	17722327	17722327	C	T	exonic	SREBF1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs142128892	chr17	17720323	17720323	G	A	exonic	SREBF1	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr17	17726853	17726853	C	A	exonic	SREBF1	nonsynonymous	THYM\|1\|123\|0.00813
rs766878437	chr17	17720322	17720322	C	T	exonic	SREBF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs377727800	chr17	17720399	17720399	T	C	exonic	SREBF1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr17	17723446	17723446	G	A	exonic	SREBF1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr17	17720656	17720656	A	G	exonic	SREBF1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr17	17722388	17722388	C	T	exonic	SREBF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs371247619	chr17	17722891	17722891	A	G	exonic	SREBF1	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr17	17722393	17722393	G	A	exonic	SREBF1	synonymous	PAAD\|1\|185\|0.00541
-	chr17	17723627	17723627	G	T	exonic	SREBF1	synonymous	HNSC\|1\|512\|0.00195
-	chr17	17717650	17717650	G	C	exonic	SREBF1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189

Disease information of SREBF1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
SREBF1	Alloxan Diabetes	C18;C19	Experimental Model of Disease	CTD_human
SREBF1	Diabetes Mellitus, Experimental	C18;C19	Experimental Model of Disease	CTD_human
SREBF1	Fatty Liver	C06	Disease or Syndrome	CTD_human
SREBF1	Insulin Resistance	C18	Pathologic Function	CTD_human
SREBF1	Kidney Failure, Chronic	C12;C13	Disease or Syndrome	CTD_human
SREBF1	Liver Cirrhosis, Experimental	C06	Experimental Model of Disease	CTD_human
SREBF1	Obesity	C18;C23	Disease or Syndrome	CTD_human
SREBF1	Schizophrenia	F03	Mental or Behavioral Dysfunction	PSYGENET
SREBF1	Streptozotocin Diabetes	C18;C19	Experimental Model of Disease	CTD_human
SREBF1	Non-alcoholic Fatty Liver Disease	C06	Disease or Syndrome	CTD_human
SREBF1	Insulin Sensitivity	C18	Pathologic Function	CTD_human
SREBF1	Liver carcinoma	C04;C06	Neoplastic Process	CTD_human
SREBF1	Steatohepatitis	C06	Disease or Syndrome	CTD_human
SREBF1	Nonalcoholic Steatohepatitis	C06	Disease or Syndrome	CTD_human

Pathway associated with SREBF1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000069	Activation of gene expression by SREBF (SREBP)	reactome	42	266
pathway0001078	ID	netpath	38	213
pathway0001828	Regulation of cholesterol biosynthesis by SREBP (SREBF)	reactome	15	53
pathway0001940	RORA activates gene expression	reactome	27	204
pathway0001947	RXR and RAR heterodimerization with other nuclear receptor	pid	26	164
pathway0002700	Hs_Signaling_of_Hepatocyte_Growth_Factor_Receptor_WP313_79946	wikipathways	15	18
pathway0002798	Hs_AMP-activated_Protein_Kinase_(AMPK)_Signaling_WP1403_90259	wikipathways	11	15
pathway0002806	Hs_Sterol_Regulatory_Element-Binding_Proteins_(SREBP)_signalling_WP1982_90425	wikipathways	15	31
pathway0002857	Hs_SREBF_and_miR33_in_cholesterol_and_lipid_homeostasis_WP2011_89947	wikipathways	6	12
pathway0002878	Hs_ID_signaling_pathway_WP53_67360	wikipathways	8	12

Go term information of SREBF1

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GO_term_name	GO_term_type	TF_name
GO_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS	BP	SREBF1
GO_REGULATION_OF_HISTONE_DEACETYLATION	BP	SREBF1
GO_REGULATION_OF_PROTEIN_DEACETYLATION	BP	SREBF1
GO_REGULATION_OF_HORMONE_LEVELS	BP	SREBF1
GO_RESPONSE_TO_FOOD	BP	SREBF1
GO_POSITIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS	BP	SREBF1
GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION	BP	SREBF1
GO_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS	BP	SREBF1
GO_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS	BP	SREBF1
GO_POSITIVE_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS	BP	SREBF1
GO_RESPONSE_TO_GLUCAGON	BP	SREBF1
GO_POSITIVE_REGULATION_OF_HISTONE_DEACETYLATION	BP	SREBF1
GO_REGULATION_OF_LIPID_METABOLIC_PROCESS	BP	SREBF1
GO_RESPONSE_TO_CAMP	BP	SREBF1
GO_NEGATIVE_REGULATION_OF_PROTEIN_SECRETION	BP	SREBF1
GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS	BP	SREBF1
GO_POSITIVE_REGULATION_OF_CHROMATIN_MODIFICATION	BP	SREBF1
GO_REGULATION_OF_MITOPHAGY	BP	SREBF1
GO_RESPONSE_TO_PROGESTERONE	BP	SREBF1
GO_CELLULAR_RESPONSE_TO_FATTY_ACID	BP	SREBF1
GO_MRNA_TRANSCRIPTION	BP	SREBF1
GO_POSITIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION	BP	SREBF1
GO_POSITIVE_REGULATION_OF_PROTEIN_DEACETYLATION	BP	SREBF1
GO_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS	BP	SREBF1
GO_RESPONSE_TO_RETINOIC_ACID	BP	SREBF1
GO_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS	BP	SREBF1
GO_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS	BP	SREBF1
GO_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS	BP	SREBF1
GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS	BP	SREBF1
GO_POSITIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS	BP	SREBF1
GO_REGULATION_OF_PROTEIN_TARGETING	BP	SREBF1
GO_MRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	SREBF1
GO_ER_TO_GOLGI_TRANSPORT_VESICLE	CC	SREBF1
GO_ER_TO_GOLGI_TRANSPORT_VESICLE_MEMBRANE	CC	SREBF1
GO_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK	CC	SREBF1
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING	MF	SREBF1
GO_CHROMATIN_BINDING	MF	SREBF1
GO_CORE_PROMOTER_PROXIMAL_REGION_DNA_BINDING	MF	SREBF1

Survival analysis of SREBF1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of SREBF1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)