Sample overview of Colo205

Sample ID: Sample_02_354
Biosample type: Cell line
Tissue type: Colon
Biosample name: Colo205
Data source: NCBI GEO/SRA
GSE ID: GSE73319
Cancer type: Colorectal Cancer
CRC number: 666
TF number of all CRCs: 49
TF list of all CRCs: ELF3, RARA, KLF5, EHF, TCF7, SREBF1, MYB, RREB1, SMAD3, HNF1A, SP1, RUNX1, FOS, TEAD1, RXRA, YY1, SRF, PDX1, JUNB, ZBTB7C, TCF7L2, SREBF2, PITX1, TGIF1, FOXA2, ASCL2, BHLHE40, ZBTB7B, NFE2L2, HNF1B, FOSL2, ELF1, MYC, MSX2, SOX13, FOSL1, ETS2, KLF3, HES1, FOXB1, IRF2, ZIC2, ZBTB7A, PPARA, CREB3L2, ZNF217, NFYA, MNT, BARX2

The most representative CRC of Colo205
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Relationship plot of CRC model
TF number of this CRC: 18
CRC socre: 480.3333
TF list of the most representative CRC
TF name TF family Frequency of TFs
ASCL2 bHLH 281 / 666
EHF ETS 666 / 666
ELF3 ETS 666 / 666
HNF1A Homeobox 539 / 666
HNF1B Homeobox 241 / 666
KLF5 zf-C2H2 666 / 666
MYB MYB 613 / 666
NFYA NF-YA 60 / 666
RARA THR-like 666 / 666
RUNX1 Runt 487 / 666
RXRA RXR-like 399 / 666
SMAD3 MH1 539 / 666
SP1 zf-C2H2 490 / 666
SREBF1 bHLH 651 / 666
TCF7 HMG 651 / 666
TCF7L2 HMG 316 / 666
YY1 zf-C2H2 396 / 666
ZBTB7C ZBTB 319 / 666

All CRCs of Colo205
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CRC rank TF list of CRCs CRC score TF number of CRC Detail of CRC

Frequency of TFs that appear in CRCs
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TF name Frequency of TFs TF family Ensembl ID
KLF5 666 / 666 zf-C2H2 ENSG00000102554
RARA 666 / 666 THR-like ENSG00000131759
EHF 666 / 666 ETS ENSG00000135373
ELF3 666 / 666 ETS ENSG00000163435
SREBF1 651 / 666 bHLH ENSG00000072310
TCF7 651 / 666 HMG ENSG00000081059
MYB 613 / 666 MYB ENSG00000118513
RREB1 606 / 666 zf-C2H2 ENSG00000124782
HNF1A 539 / 666 Homeobox ENSG00000135100
SMAD3 539 / 666 MH1 ENSG00000166949
SP1 490 / 666 zf-C2H2 ENSG00000185591
RUNX1 487 / 666 Runt ENSG00000159216
FOS 413 / 666 TF_bZIP ENSG00000170345
TEAD1 412 / 666 TEA ENSG00000187079
RXRA 399 / 666 RXR-like ENSG00000186350
YY1 396 / 666 zf-C2H2 ENSG00000100811
SRF 378 / 666 SRF ENSG00000112658
PDX1 340 / 666 Homeobox ENSG00000139515
JUNB 333 / 666 TF_bZIP ENSG00000171223
ZBTB7C 319 / 666 ZBTB ENSG00000184828
TCF7L2 316 / 666 HMG ENSG00000148737
SREBF2 303 / 666 bHLH ENSG00000198911
PITX1 302 / 666 Homeobox ENSG00000069011
TGIF1 282 / 666 Homeobox ENSG00000177426
FOXA2 282 / 666 Fork_head ENSG00000125798
ASCL2 281 / 666 bHLH ENSG00000183734
BHLHE40 281 / 666 bHLH ENSG00000134107
ZBTB7B 280 / 666 ZBTB ENSG00000160685
NFE2L2 247 / 666 TF_bZIP ENSG00000116044
HNF1B 241 / 666 Homeobox ENSG00000275410
FOSL2 209 / 666 TF_bZIP ENSG00000075426
ELF1 204 / 666 ETS ENSG00000120690
MYC 203 / 666 bHLH ENSG00000136997
MSX2 140 / 666 Homeobox ENSG00000120149
SOX13 138 / 666 HMG ENSG00000143842
FOSL1 127 / 666 TF_bZIP ENSG00000175592
ETS2 120 / 666 ETS ENSG00000157557
KLF3 108 / 666 zf-C2H2 ENSG00000109787
HES1 102 / 666 bHLH ENSG00000114315
FOXB1 96 / 666 Fork_head ENSG00000171956
IRF2 91 / 666 IRF ENSG00000168310
ZIC2 83 / 666 zf-C2H2 ENSG00000043355
ZBTB7A 80 / 666 ZBTB ENSG00000178951
PPARA 80 / 666 THR-like ENSG00000186951
CREB3L2 80 / 666 TF_bZIP ENSG00000182158
ZNF217 72 / 666 zf-C2H2 ENSG00000171940
NFYA 60 / 666 NF-YA ENSG00000001167
MNT 53 / 666 bHLH ENSG00000070444
BARX2 15 / 666 Homeobox ENSG00000043039

Indegree and outdegree of TFs
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TF name Indegree Outdegree Node connections
PPARA 38 79 117
ZNF217 51 48 99
SOX13 46 81 127
YY1 50 81 131
FOSL1 38 77 115
TCF7 53 82 135
SMAD3 54 81 135
ZIC2 38 77 115
NFYA 33 72 105
ZBTB7A 53 58 111
ELF1 47 82 129
TEAD1 51 76 127
ELF3 54 81 135
RREB1 54 79 133
RARA 53 81 134
CREB3L2 49 64 113
PITX1 53 71 124
ZBTB7C 50 75 125
NFE2L2 51 73 124
MNT 52 56 108
HNF1B 51 75 126
ASCL2 49 81 130
KLF5 54 79 133
SREBF1 53 79 132
KLF3 50 67 117
HNF1A 52 79 131
FOSL2 54 71 125
FOXB1 39 79 118
MSX2 49 73 122
MYB 52 81 133
JUNB 52 75 127
SRF 48 82 130
ZBTB7B 51 75 126
FOS 54 75 129
SP1 50 81 131
RXRA 49 82 131
EHF 53 81 134
PDX1 50 79 129
MYC 53 71 124
IRF2 42 81 123
BARX2 45 46 91
FOXA2 53 78 131
SREBF2 49 79 128
TCF7L2 50 77 127
BHLHE40 54 74 128
RUNX1 53 81 134
HES1 51 65 116
ETS2 54 62 116
TGIF1 52 77 129

Expression of TFs in all CRCs