TF information

TF name: FOXA2
TF family: Fork_head
Ensembl gene ID: ENSG00000125798
Ensembl protein ID: ENSP00000366319, ENSP00000400341
Entrez gene ID: 3170
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:

Frequency of FOXA2 in all biosamples
Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_02_280Cell lineMammary GlandSUM159_DMSO_24h0.20833333333333
Sample_02_285Cell lineLiverHuH7_untreat1
Sample_02_322Cell lineColonCaco-20.30551816958277
Sample_02_354Cell lineColonColo2050.42342342342342
Sample_02_424Cell lineColonSW6201

FOXA2 distribution in samples’ most representative CRC
Sample ID Tissue type Biosample type Biosample name
Sample_02_285LiverCell lineHuH7_untreat
Sample_02_424ColonCell lineSW620

FOXA2 distribution in all CRCs
Biosample type
Biosample name
Sample ID

Genomic distribution of SEs associated with FOXA2
Download

Mutation of FOXA2
Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of FOXA2

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
-chr202256290422562904CTexonicFOXA2nonsynonymous SKCM|1|368|0.00272
rs760812511chr202256315322563153GAexonicFOXA2nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204,KIPAN|1|799|0.00125,KIRP|1|282|0.00355
-chr202256275722562757-TexonicFOXA2frameshift UCEC|1|248|0.00403
-chr202256249222562492GCexonicFOXA2nonsynonymous BLCA|1|396|0.00253
-chr202256346222563462TGexonicFOXA2nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs750349218chr202256349622563496GTexonicFOXA2synonymous BLCA|1|396|0.00253
-chr202256321122563211GAexonicFOXA2synonymous CESC|1|194|0.00515
-chr202256283622562836CTexonicFOXA2synonymous DLBC|1|48|0.02083
rs779405437chr202256267722562677GCexonicFOXA2nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189,PAAD|1|185|0.00541,PRAD|1|499|0.00200,TGCT|1|155|0.00645
-chr202256370522563705TCexonicFOXA2nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr202256264622562646CTexonicFOXA2nonsynonymous SKCM|1|368|0.00272
-chr202256267422562675TT-exonicFOXA2frameshift PAAD|1|185|0.00541
-chr202256334322563343CAexonicFOXA2nonsynonymous OV|1|469|0.00213
-chr202256342122563421GAexonicFOXA2synonymous SKCM|1|368|0.00272
rs745674979chr202256271422562714GAexonicFOXA2nonsynonymous SKCM|1|368|0.00272
rs777713858chr202256279422562794CTexonicFOXA2synonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
-chr202256486822564868CAexonicFOXA2stopgain STAD|1|395|0.00253,STES|1|395|0.00253
-chr202256324122563241GCexonicFOXA2nonsynonymous UCS|1|57|0.01754
rs151323690chr202256348122563481GAexonicFOXA2synonymous PRAD|1|499|0.00200
-chr202256249422562494GTexonicFOXA2synonymous UCEC|1|248|0.00403
-chr202256313422563134AGexonicFOXA2nonsynonymous DLBC|1|48|0.02083
-chr202256335022563350GAexonicFOXA2nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr202256370822563708CTexonicFOXA2nonsynonymous SKCM|1|368|0.00272
-chr202256284622562846GAexonicFOXA2nonsynonymous THYM|1|123|0.00813
-chr202256265722562657ATexonicFOXA2nonsynonymous UCEC|1|248|0.00403
-chr202256319322563193C-exonicFOXA2frameshift UCEC|1|248|0.00403
-chr202256334522563345GTexonicFOXA2nonsynonymous COAD|2|367|0.00545,COADREAD|2|489|0.00409
-chr202256367622563676GAexonicFOXA2synonymous SKCM|1|368|0.00272
-chr202256286522562865GAexonicFOXA2nonsynonymous UCEC|1|248|0.00403
-chr202256331322563313GCexonicFOXA2nonsynonymous PCPG|1|184|0.00543
-chr202256334022563340CGexonicFOXA2nonsynonymous BLCA|1|396|0.00253
-chr202256262622562626GAexonicFOXA2synonymous BLCA|1|396|0.00253
-chr202256319822563198GAexonicFOXA2nonsynonymous UCS|1|57|0.01754
-chr202256331722563317ATexonicFOXA2nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr202256351222563512GAexonicFOXA2nonsynonymous PRAD|1|499|0.00200
-chr202256280722562807GAexonicFOXA2nonsynonymous BLCA|1|396|0.00253
-chr202256354422563544CGexonicFOXA2nonsynonymous CESC|1|194|0.00515
-chr202256366522563665GTexonicFOXA2stopgain UCS|1|57|0.01754
-chr202256339022563390CTexonicFOXA2nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr202256346322563463CTexonicFOXA2nonsynonymous SKCM|1|368|0.00272
-chr202256313222563132CAexonicFOXA2stopgain UCEC|1|248|0.00403
-chr202256331122563311TCexonicFOXA2nonsynonymous HNSC|1|512|0.00195
-chr202256293822562987GGCGCTCGAGTGAGGCGACTCGGTGCCCGCCGGAGTCTCGGAGGCCGGCC-exonicFOXA2frameshift -
-chr202256375022563750TGexonicFOXA2nonsynonymous OV|1|469|0.00213
-chr202256361922563619GCexonicFOXA2synonymous HNSC|1|512|0.00195
rs745424789chr202256339022563390CAexonicFOXA2nonsynonymous LUAD|2|543|0.00368
-chr202256487422564874CTexonicFOXA2nonsynonymous UCEC|1|248|0.00403
-chr202256376622563766GAexonicFOXA2synonymous HNSC|1|512|0.00195
-chr202256271122562711GAexonicFOXA2nonsynonymous CESC|1|194|0.00515
-chr202256338222563402CGGCTTTGCGTGCGTGTAGCT-exonicFOXA2nonframeshift UCEC|1|248|0.00403
rs774841083chr202256324622563246AGexonicFOXA2nonsynonymous COADREAD|1|489|0.00204,READ|1|122|0.00820
-chr202256268822562688GAexonicFOXA2nonsynonymous SKCM|1|368|0.00272
-chr202256327722563277GAexonicFOXA2synonymous BLCA|1|396|0.00253,SKCM|1|368|0.00272
-chr202256316022563160GAexonicFOXA2synonymous ACC|1|90|0.01111
-chr202256374822563748GAexonicFOXA2synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs773365412chr202256311822563118GAexonicFOXA2synonymous ESCA|1|185|0.00541
-chr202256313222563132CTexonicFOXA2nonsynonymous SKCM|1|368|0.00272
-chr202256294522562945GCexonicFOXA2nonsynonymous BLCA|1|396|0.00253
-chr202256364322563643CTexonicFOXA2nonsynonymous LUAD|1|543|0.00184
-chr202256322722563227GAexonicFOXA2nonsynonymous HNSC|1|512|0.00195
-chr202256332922563329TGexonicFOXA2nonsynonymous CHOL|1|35|0.02857
-chr202256271922562719GAexonicFOXA2synonymous BLCA|1|396|0.00253
-chr202256283922562839C-exonicFOXA2frameshift UCEC|1|248|0.00403
-chr202256368522563685GCexonicFOXA2nonsynonymous LUAD|1|543|0.00184
-chr202256337422563374GAexonicFOXA2nonsynonymous UCEC|1|248|0.00403
-chr202256486022564860GAexonicFOXA2synonymous SKCM|1|368|0.00272
-chr202256352722563527GAexonicFOXA2nonsynonymous SKCM|1|368|0.00272
-chr202256348522563485GAexonicFOXA2nonsynonymous SKCM|1|368|0.00272
rs771400505chr202256342022563420GAexonicFOXA2nonsynonymous SKCM|1|368|0.00272
-chr202256340522563405GAexonicFOXA2nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr202256284222562842CGexonicFOXA2synonymous SARC|1|247|0.00405
-chr202256278522562785CAexonicFOXA2synonymous LIHC|1|373|0.00268
-chr202256363022563630CAexonicFOXA2nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs769823311chr202256368422563684CTexonicFOXA2nonsynonymous DLBC|1|48|0.02083
-chr202256268322562683GCexonicFOXA2nonsynonymous PRAD|1|499|0.00200
-chr202256261522562615GAexonicFOXA2nonsynonymous SKCM|1|368|0.00272
rs774892375chr202256309122563091GAexonicFOXA2synonymous ESCA|1|185|0.00541
-chr202256257822562578CTexonicFOXA2synonymous SKCM|1|368|0.00272
rs780546461chr202256359522563595GAexonicFOXA2synonymous HNSC|1|512|0.00195,STAD|1|395|0.00253,STES|1|395|0.00253
rs558508968chr202256287222562872CTexonicFOXA2synonymous BRCA|1|982|0.00102
-chr202256334522563345GAexonicFOXA2stopgain COAD|1|367|0.00272,COADREAD|1|489|0.00204,UCEC|1|248|0.00403
-chr202256316522563165ATexonicFOXA2nonsynonymous UCEC|1|248|0.00403

Disease information of FOXA2
TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source
FOXA2 Diaphragmatic Hernia C23 Anatomical Abnormality CTD_human
FOXA2 Liver Cirrhosis, Experimental C06 Experimental Model of Disease CTD_human
FOXA2 Lung diseases C08 Disease or Syndrome CTD_human

Pathway associated with FOXA2
pathway_ID pathway_name pathway_source gene_number edge_number
pathway0000824 FOXA1 transcription factor network pid 45 204
pathway0000825 FOXA2 and FOXA3 transcription factor networks pid 45 202
pathway0000996 Hedgehog signaling events mediated by Gli proteins pid 49 297
pathway0001834 Regulation of gene expression in beta cells reactome 17 54
pathway0002631 Maturity onset diabetes of the young kegg 25 76
pathway0002740 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62 260
pathway0002746 Hs_Dopaminergic_Neurogenesis_WP2855_87239 wikipathways 19 37
pathway0002768 Hs_Heart_Development_WP1591_90186 wikipathways 28 78
pathway0002841 Hs_Ectoderm_Differentiation_WP2858_89329 wikipathways 56 137

Go term information of FOXA2
GO_term_name GO_term_type TF_name
GO_REGULATION_OF_WOUND_HEALING BP FOXA2
GO_REGULATION_OF_CELL_CELL_ADHESION_MEDIATED_BY_CADHERIN BP FOXA2
GO_NEGATIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION BP FOXA2
GO_PRIMITIVE_STREAK_FORMATION BP FOXA2
GO_NEGATIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION BP FOXA2
GO_GASTRULATION_WITH_MOUTH_FORMING_SECOND BP FOXA2
GO_REGULATION_OF_SECRETION BP FOXA2
GO_REGULATION_OF_PEPTIDE_TRANSPORT BP FOXA2
GO_ENDOCRINE_PANCREAS_DEVELOPMENT BP FOXA2
GO_REGULATION_OF_HORMONE_SECRETION BP FOXA2
GO_REGULATION_OF_HEXOKINASE_ACTIVITY BP FOXA2
GO_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS BP FOXA2
GO_REGULATION_OF_GASTRULATION BP FOXA2
GO_CELLULAR_RESPONSE_TO_NUTRIENT BP FOXA2
GO_NEGATIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS BP FOXA2
GO_RESPONSE_TO_INTERLEUKIN_6 BP FOXA2
GO_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION BP FOXA2
GO_ENDOCRINE_SYSTEM_DEVELOPMENT BP FOXA2
GO_REGULATION_OF_EMBRYONIC_DEVELOPMENT BP FOXA2
GO_DOPAMINERGIC_NEURON_DIFFERENTIATION BP FOXA2
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_INVOLVED_IN_CELLULAR_RESPONSE_TO_CHEMICAL_STIMULUS BP FOXA2
GO_POSITIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT BP FOXA2
GO_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION BP FOXA2

Survival analysis of FOXA2



Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of FOXA2