Cancer CRCdb

TF information

TF name:	ETS2
TF family:	ETS
Ensembl gene ID:	ENSG00000157557
Ensembl protein ID:	ENSP00000354194, ENSP00000353344
Entrez gene ID:	2114

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of ETS2 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_001	Cell line	Prostate	22Rv1	0.072639225181598
Sample_02_021	Cell line	Colon	V429	0.22917267223984
Sample_02_029	Cell line	Colorectal	LS174T	0.33333333333333
Sample_02_080	Cell line	Lung	Calu-3	0.45454545454545
Sample_02_164	Cell line	Lung	H2087_Parental	0.083333333333333
Sample_02_166	Cell line	Mammary Gland	HCC1954_Parental	0.16
Sample_02_199	Cell line	Stomach	KATO3	0.33333333333333
Sample_02_205	Tissue	Stomach	Gastric_Primary_Sample_T	0.22222222222222
Sample_02_236	Cell line	Colon	V206	0.21325051759834
Sample_02_237	Cell line	Colon	V389	0.12619179090742
Sample_02_241	Cell line	Colon	V456	0.19074492099323
Sample_02_242	Cell line	Colon	V481	0.11113247452413
Sample_02_268	Cell line	Kidney	A-498	0.028059811703895
Sample_02_280	Cell line	Mammary Gland	SUM159_DMSO_24h	0.2
Sample_02_311	Cell line	Neuroblastoma	SK-N-AS	0.18181818181818
Sample_02_354	Cell line	Colon	Colo205	0.18018018018018
Sample_02_355	Cell line	Colon	HCT15	0.18452380952381
Sample_02_358	Cell line	Colon	LS180	0.13309636650869
Sample_02_361	Cell line	Colon	HT29_DMSO	0.11327433628319

ETS2 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_080	Lung	Cell line	Calu-3
Sample_02_205	Stomach	Tissue	Gastric_Primary_Sample_T
Sample_02_280	Mammary Gland	Cell line	SUM159_DMSO_24h
Sample_02_311	Neuroblastoma	Cell line	SK-N-AS

ETS2 distribution in all CRCs

Genomic distribution of SEs associated with ETS2

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Mutation of ETS2

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of ETS2

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
rs113417859	chr21	40191548	40191548	C	T	exonic	ETS2	synonymous	PAAD\|1\|185\|0.00541,SKCM\|1\|368\|0.00272
-	chr21	40181960	40181960	T	C	exonic	ETS2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr21	40190389	40190389	G	A	exonic	ETS2	synonymous	PRAD\|1\|499\|0.00200
-	chr21	40191545	40191545	C	T	exonic	ETS2	synonymous	SKCM\|1\|368\|0.00272
-	chr21	40191681	40191681	G	T	exonic	ETS2	nonsynonymous	OV\|1\|469\|0.00213
-	chr21	40190568	40190568	C	-	exonic	ETS2	frameshift	HNSC\|1\|512\|0.00195
-	chr21	40191503	40191503	G	A	exonic	ETS2	stopgain	SKCM\|1\|368\|0.00272
-	chr21	40194662	40194662	G	A	exonic	ETS2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr21	40190402	40190402	G	A	exonic	ETS2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr21	40194793	40194793	C	T	exonic	ETS2	stopgain	BLCA\|1\|396\|0.00253
-	chr21	40191453	40191453	G	A	exonic	ETS2	nonsynonymous	HNSC\|2\|512\|0.00391
rs751784308	chr21	40191600	40191600	A	G	exonic	ETS2	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr21	40191577	40191577	C	T	exonic	ETS2	nonsynonymous	LUAD\|1\|543\|0.00184
rs150592938	chr21	40182008	40182008	A	G	exonic	ETS2	nonsynonymous	BLCA\|1\|396\|0.00253
rs61735785	chr21	40190408	40190408	C	A	exonic	ETS2	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr21	40186267	40186267	T	C	exonic	ETS2	synonymous	HNSC\|1\|512\|0.00195
-	chr21	40191467	40191467	C	G	exonic	ETS2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr21	40191500	40191500	C	T	exonic	ETS2	synonymous	SKCM\|1\|368\|0.00272
-	chr21	40191520	40191520	T	A	exonic	ETS2	stopgain	BRCA\|1\|982\|0.00102
-	chr21	40190484	40190484	C	T	exonic	ETS2	nonsynonymous	SKCM\|1\|368\|0.00272
rs768875008	chr21	40194678	40194678	C	T	exonic	ETS2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr21	40191440	40191440	C	A	exonic	ETS2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	40186253	40186253	C	G	exonic	ETS2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr21	40184981	40184981	C	-	exonic	ETS2	stopgain	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443
-	chr21	40186841	40186841	T	A	exonic	ETS2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr21	40186899	40186899	A	T	exonic	ETS2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr21	40186286	40186286	A	C	exonic	ETS2	nonsynonymous	LIHC\|1\|373\|0.00268
rs762854102	chr21	40194713	40194713	G	A	exonic	ETS2	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr21	40193623	40193623	G	A	exonic	ETS2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,HNSC\|1\|512\|0.00195
-	chr21	40188989	40188989	C	A	exonic	ETS2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr21	40190507	40190507	A	C	exonic	ETS2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr21	40184979	40184979	C	T	exonic	ETS2	nonsynonymous	SKCM\|1\|368\|0.00272
rs765105270	chr21	40193595	40193595	C	T	exonic	ETS2	synonymous	PRAD\|1\|499\|0.00200
-	chr21	40186843	40186843	T	C	exonic	ETS2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr21	40194729	40194729	C	T	exonic	ETS2	synonymous	BRCA\|1\|982\|0.00102,UCEC\|1\|248\|0.00403
-	chr21	40188949	40188949	G	T	exonic	ETS2	stopgain	ACC\|1\|90\|0.01111
-	chr21	40189001	40189001	A	G	exonic	ETS2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr21	40191596	40191596	A	G	exonic	ETS2	synonymous	SKCM\|1\|368\|0.00272
rs753854772	chr21	40186743	40186743	C	T	exonic	ETS2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs747282020	chr21	40186851	40186851	G	A	exonic	ETS2	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr21	40194604	40194604	C	T	exonic	ETS2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs777392517	chr21	40194635	40194635	A	C	exonic	ETS2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr21	40193564	40193564	C	T	exonic	ETS2	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr21	40188980	40188980	C	T	exonic	ETS2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr21	40194639	40194639	G	C	exonic	ETS2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr21	40194761	40194761	C	T	exonic	ETS2	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr21	40186898	40186898	G	A	exonic	ETS2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr21	40194739	40194739	C	A	exonic	ETS2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr21	40194812	40194812	G	T	exonic	ETS2	stoploss	HNSC\|2\|512\|0.00391
-	chr21	40194646	40194646	G	A	exonic	ETS2	nonsynonymous	HNSC\|2\|512\|0.00391
rs184634189	chr21	40186201	40186201	C	T	exonic	ETS2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr21	40191431	40191431	T	C	exonic	ETS2	synonymous	LIHC\|1\|373\|0.00268
-	chr21	40185005	40185005	G	T	exonic	ETS2	stopgain	UCEC\|1\|248\|0.00403
rs753377257	chr21	40194777	40194777	C	T	exonic	ETS2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr21	40194762	40194762	G	A	exonic	ETS2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	40181971	40181971	G	A	exonic	ETS2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr21	40185002	40185002	C	T	exonic	ETS2	stopgain	UCEC\|1\|248\|0.00403
-	chr21	40191608	40191608	C	T	exonic	ETS2	synonymous	SKCM\|1\|368\|0.00272
-	chr21	40184981	40184981	C	G	exonic	ETS2	nonsynonymous	CESC\|1\|194\|0.00515
rs777149491	chr21	40191444	40191444	G	A	exonic	ETS2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr21	40190520	40190520	T	C	exonic	ETS2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr21	40194596	40194596	A	C	splicing	ETS2	splicing	LUAD\|1\|543\|0.00184
-	chr21	40193587	40193592	ACTGGA	-	exonic	ETS2	nonframeshift	UCEC\|1\|248\|0.00403
rs770842891	chr21	40194717	40194717	C	T	exonic	ETS2	synonymous	UCEC\|1\|248\|0.00403
-	chr21	40191551	40191551	G	A	exonic	ETS2	synonymous	BLCA\|1\|396\|0.00253
-	chr21	40184975	40184975	C	T	exonic	ETS2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr21	40184962	40184962	G	A	exonic	ETS2	synonymous	PAAD\|1\|185\|0.00541
-	chr21	40190487	40190487	G	A	exonic	ETS2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr21	40194759	40194759	C	T	exonic	ETS2	synonymous	LUAD\|2\|543\|0.00368
-	chr21	40191432	40191432	C	T	exonic	ETS2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr21	40191522	40191522	C	T	exonic	ETS2	synonymous	LUAD\|1\|543\|0.00184
rs201065633	chr21	40191557	40191557	C	T	exonic	ETS2	synonymous	BLCA\|1\|396\|0.00253,SKCM\|2\|368\|0.00543
-	chr21	40190548	40190548	G	C	exonic	ETS2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr21	40191655	40191655	C	T	exonic	ETS2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr21	40194699	40194699	G	T	exonic	ETS2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr21	40186831	40186831	A	C	exonic	ETS2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	40186315	40186315	G	C	exonic	ETS2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr21	40190562	40190562	A	G	exonic	ETS2	nonsynonymous	UCEC\|1\|248\|0.00403
rs755069743	chr21	40191474	40191474	G	A	exonic	ETS2	nonsynonymous	HNSC\|1\|512\|0.00195

Disease information of ETS2

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
ETS2	Malignant neoplasm of breast	C04;C17	Neoplastic Process	CTD_human
ETS2	Nerve Degeneration	C23	Cell or Molecular Dysfunction	CTD_human
ETS2	Dermatitis, Allergic Contact	C17;C20	Disease or Syndrome	CTD_human
ETS2	Craniofacial Abnormalities	C05;C16	Congenital Abnormality	CTD_human
ETS2	Breast Carcinoma	C04;C17	Neoplastic Process	CTD_human
ETS2	Mammary Neoplasms, Human	C04;C17	Neoplastic Process	CTD_human
ETS2	Mammary Neoplasms	C04;C17	Neoplastic Process	CTD_human

Pathway associated with ETS2

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000335	C-MYB transcription factor network	pid	87	525
pathway0000702	ERK cascade ( FGF8 signaling (Mouse) )	inoh	17	71
pathway0000703	ERK cascade ( FGF8 signaling (Xenopus) )	inoh	17	71
pathway0000781	FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) )	inoh	20	66
pathway0000782	FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) )	inoh	18	53
pathway0001078	ID	netpath	38	213
pathway0001120	IL2	netpath	81	1364
pathway0001543	Oncogene Induced Senescence	reactome	30	146
pathway0002565	MAPK signaling pathway - fly	kegg	16	62
pathway0002588	Dorso-ventral axis formation	kegg	25	58

Go term information of ETS2

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GO_term_name	GO_term_type	TF_name
GO_AXIS_SPECIFICATION	BP	ETS2
GO_PRIMITIVE_STREAK_FORMATION	BP	ETS2
GO_GASTRULATION_WITH_MOUTH_FORMING_SECOND	BP	ETS2
GO_ECTODERM_DEVELOPMENT	BP	ETS2
GO_CELL_FATE_COMMITMENT_INVOLVED_IN_FORMATION_OF_PRIMARY_GERM_LAYER	BP	ETS2
GO_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION	BP	ETS2
GO_HORMONE_RECEPTOR_BINDING	MF	ETS2
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING	MF	ETS2
GO_GLUCOCORTICOID_RECEPTOR_BINDING	MF	ETS2

Survival analysis of ETS2

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of ETS2

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)