TF information

TF name: RXRA
TF family: RXR-like
Ensembl gene ID: ENSG00000186350
Ensembl protein ID: ENSP00000419692
Entrez gene ID: 6256
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:

Frequency of RXRA in all biosamples
Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_01_022Cell lineProstateC4-2B0.78571428571429
Sample_01_046Cell lineMammary GlandMCF-71
Sample_01_068Cell lineProstate: derived from metastatic site: vertebral metastasisVCaP0.54794520547945
Sample_02_007OtherCervicalcervical-cancer_vector0.6953642384106
Sample_02_079Cell lineMammary GlandT-47D_10.22222222222222
Sample_02_096Cell lineMammary GlandZR-75-1_11
Sample_02_115Cell lineMammary GlandMCF-70.6
Sample_02_164Cell lineLungH2087_Parental0.98333333333333
Sample_02_166Cell lineMammary GlandHCC1954_Parental0.728
Sample_02_168Cell lineProstateLNCaP0.73384030418251
Sample_02_227Cell lineOesophagusTE71
Sample_02_228Cell lineOesophagusKYSE5100.97949673811743
Sample_02_237Cell lineColonV3890.46751334437696
Sample_02_250TissueBraintumormodel36910.625
Sample_02_254Cell lineNeuroblastomaIMR5-751
Sample_02_267Cell lineKidney786-O0.6
Sample_02_268Cell lineKidneyA-4980.068303489016061
Sample_02_280Cell lineMammary GlandSUM159_DMSO_24h0.78333333333333
Sample_02_296Cell lineNeuroblastomaCLB-BER-Lud0.3840856924254
Sample_02_300Cell lineNeuroblastomaCLB-PE0.56410256410256
Sample_02_303Cell lineNeuroblastomaLAN10.45714285714286
Sample_02_307Cell lineNeuroblastomaSJNB120.3943661971831
Sample_02_308Cell lineNeuroblastomaSJNB10.34375
Sample_02_309Cell lineNeuroblastomaSJNB60.48815165876777
Sample_02_312Cell lineNeuroblastomaSK-N-BE_2-C0.52659574468085
Sample_02_316Cell lineNeuroblastomaCHP2120.48351648351648
Sample_02_354Cell lineColonColo2050.5990990990991
Sample_02_361Cell lineColonHT29_DMSO0.34159292035398
Sample_02_394Cell lineMammary GlandT-47D_20.30769230769231
Sample_02_403Cell lineMammary GlandT-47D_untreat0.59090909090909
Sample_02_404Cell lineMammary GlandZR-75-1_20.46043165467626

RXRA distribution in samples’ most representative CRC
Sample ID Tissue type Biosample type Biosample name
Sample_01_022ProstateCell lineC4-2B
Sample_01_046Mammary GlandCell lineMCF-7
Sample_01_068Prostate: derived from metastatic site: vertebral metastasisCell lineVCaP
Sample_02_007CervicalOthercervical-cancer_vector
Sample_02_096Mammary GlandCell lineZR-75-1_1
Sample_02_164LungCell lineH2087_Parental
Sample_02_166Mammary GlandCell lineHCC1954_Parental
Sample_02_168ProstateCell lineLNCaP
Sample_02_227OesophagusCell lineTE7
Sample_02_228OesophagusCell lineKYSE510
Sample_02_237ColonCell lineV389
Sample_02_250BrainTissuetumormodel3691
Sample_02_254NeuroblastomaCell lineIMR5-75
Sample_02_267KidneyCell line786-O
Sample_02_280Mammary GlandCell lineSUM159_DMSO_24h
Sample_02_300NeuroblastomaCell lineCLB-PE
Sample_02_312NeuroblastomaCell lineSK-N-BE_2-C
Sample_02_316NeuroblastomaCell lineCHP212
Sample_02_354ColonCell lineColo205
Sample_02_361ColonCell lineHT29_DMSO
Sample_02_403Mammary GlandCell lineT-47D_untreat

RXRA distribution in all CRCs
Biosample type
Biosample name
Sample ID

Genomic distribution of SEs associated with RXRA
Download

Mutation of RXRA
Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of RXRA

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
-chr9137326002137326002AGexonicRXRAnonsynonymous OV|1|469|0.00213
-chr9137328510137328510AGUTR3RXRAunknown STAD|1|395|0.00253,STES|1|395|0.00253
-chr9137328414137328414AGexonicRXRAnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr9137300036137300036CTexonicRXRAsynonymous LUSC|1|178|0.00562
rs759299186chr9137321051137321051CTexonicRXRAsynonymous BLCA|1|396|0.00253
-chr9137300876137300876ATexonicRXRAnonsynonymous LUSC|1|178|0.00562
-chr9137328351137328351CAexonicRXRAnonsynonymous BLCA|2|396|0.00505,SARC|1|247|0.00405
-chr9137313559137313559AGexonicRXRAnonsynonymous PRAD|1|499|0.00200
rs369993354chr9137331938137331938A-UTR3RXRAunknown ESCA|1|185|0.00541,SARC|1|247|0.00405
-chr9137313586137313586G-exonicRXRAframeshift BRCA|1|982|0.00102
rs571766607chr9137300015137300015CTexonicRXRAsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr9137330373137330373CGUTR3RXRAunknown BRCA|1|982|0.00102
rs368400425chr9137323779137323779CTexonicRXRAnonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr9137300143137300143CGexonicRXRAstopgain BLCA|1|396|0.00253
-chr9137320990137320990GAexonicRXRAnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr9137321028137321028GAexonicRXRAnonsynonymous BLCA|1|396|0.00253
-chr9137300950137300950GAexonicRXRAnonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr9137328392137328392CTexonicRXRAnonsynonymous HNSC|1|512|0.00195
rs764586715chr9137293638137293638GAexonicRXRAsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
rs371715828chr9137309062137309062CTexonicRXRAsynonymous BRCA|1|982|0.00102
-chr9137293577137293577CTexonicRXRAnonsynonymous SKCM|1|368|0.00272
-chr9137313534137313534GAexonicRXRAnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr9137321010137321010GAexonicRXRAnonsynonymous PRAD|1|499|0.00200
-chr9137320993137320993CTexonicRXRAnonsynonymous SKCM|1|368|0.00272
-chr9137323760137323760GTexonicRXRAsynonymous KIPAN|1|799|0.00125,KIRP|1|282|0.00355
rs755663805chr9137325971137325971GTexonicRXRAnonsynonymous UCEC|1|248|0.00403
rs72554630chr9137313635137313635CTexonicRXRAsynonymous SKCM|1|368|0.00272
-chr9137313626137313626CTexonicRXRAsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr9137330534137330534GCUTR3RXRAunknown SARC|1|247|0.00405
-chr9137328312137328312GTsplicingRXRAsplicing UCEC|1|248|0.00403
-chr9137309042137309042GTexonicRXRAstopgain GBM|1|290|0.00345,GBMLGG|1|820|0.00122
-chr9137300902137300902CTexonicRXRAstopgain SKCM|1|368|0.00272
-chr9137313574137313574CTexonicRXRAnonsynonymous SKCM|1|368|0.00272
-chr9137328442137328442GTexonicRXRAsynonymous COAD|2|367|0.00545,COADREAD|2|489|0.00409
-chr9137300845137300845CTexonicRXRAnonsynonymous CESC|1|194|0.00515
-chr9137320990137320990GTexonicRXRAnonsynonymous LUSC|1|178|0.00562
-chr9137328331137328331CGexonicRXRAsynonymous BLCA|1|396|0.00253
-chr9137321078137321078CGexonicRXRAnonsynonymous BLCA|1|396|0.00253
-chr9137328499137328499ACUTR3RXRAunknown BRCA|1|982|0.00102
-chr9137300855137300855TCexonicRXRAnonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs777558913chr9137309085137309085CTexonicRXRAnonsynonymous BLCA|1|396|0.00253,BRCA|1|982|0.00102
-chr9137309139137309139ATexonicRXRAnonsynonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122
-chr9137293529137293529CGexonicRXRAnonsynonymous BLCA|1|396|0.00253
rs373205831chr9137321060137321060CTexonicRXRAsynonymous PRAD|1|499|0.00200
rs749580298chr9137300844137300844GAexonicRXRAsynonymous BLCA|1|396|0.00253
-chr9137293625137293625AGexonicRXRAnonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr9137323832137323832CTexonicRXRAsynonymous THCA|2|504|0.00397
-chr9137325968137325968CTexonicRXRAnonsynonymous KIPAN|1|799|0.00125,KIRP|1|282|0.00355
-chr9137328346137328346GAexonicRXRAsynonymous PAAD|1|185|0.00541
rs756234164chr9137309069137309069GAexonicRXRAnonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr9137300874137300875CA-exonicRXRAframeshift BLCA|1|396|0.00253
-chr9137293588137293588CGexonicRXRAnonsynonymous BLCA|1|396|0.00253
-chr9137293678137293678-TexonicRXRAframeshift BLCA|1|396|0.00253
-chr9137325961137325961CGexonicRXRAsynonymous ACC|1|90|0.01111
-chr9137300832137300832CTexonicRXRAsynonymous BLCA|1|396|0.00253
-chr9137293518137293518GTexonicRXRAsynonymous LUSC|1|178|0.00562
-chr9137313646137313646GAexonicRXRAnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr9137300040137300040CTexonicRXRAnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr9137293648137293648GTexonicRXRAnonsynonymous HNSC|1|512|0.00195
-chr9137293658137293658C-exonicRXRAframeshift COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr9137300040137300040C-exonicRXRAframeshift COAD|1|367|0.00272,COADREAD|1|489|0.00204,STAD|1|395|0.00253,STES|1|395|0.00253
-chr9137331939137331939A-UTR3RXRAunknown ESCA|1|185|0.00541
rs759012790chr9137328340137328340GAexonicRXRAsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr9137313652137313652GTsplicingRXRAsplicing OV|1|469|0.00213
-chr9137300121137300121GAexonicRXRAnonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs754761323chr9137300061137300061GAexonicRXRAnonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs763558005chr9137328357137328357GTexonicRXRAnonsynonymous LUAD|1|543|0.00184
rs755912201chr9137300039137300039-CexonicRXRAframeshift STAD|2|395|0.00506,STES|2|395|0.00506
-chr9137293649137293649TCexonicRXRAnonsynonymous BLCA|1|396|0.00253
-chr9137313579137313579GAexonicRXRAnonsynonymous KIPAN|1|799|0.00125,KIRP|1|282|0.00355
rs143704037chr9137300027137300027CTexonicRXRAsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr9137300887137300887CGexonicRXRAnonsynonymous BLCA|1|396|0.00253
rs760589666chr9137328325137328325CGexonicRXRAsynonymous BLCA|1|396|0.00253
-chr9137325956137325956GTexonicRXRAnonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr9137328449137328449CTexonicRXRAstopgain BLCA|1|396|0.00253
rs760095751chr9137321027137321027CTexonicRXRAsynonymous ESCA|1|185|0.00541
-chr9137321072137321072CTexonicRXRAsynonymous UCEC|1|248|0.00403
rs34683648chr9137293881137293881ACintronicRXRAunknown BRCA|1|982|0.00102
rs546006952chr9137330789137330789CTUTR3RXRAunknown CESC|1|194|0.00515
-chr9137326047137326047CAexonicRXRAnonsynonymous UCEC|1|248|0.00403
-chr9137328407137328407CTexonicRXRAnonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr9137330790137330790GAUTR3RXRAunknown CESC|1|194|0.00515
-chr9137328351137328351CTexonicRXRAnonsynonymous BLCA|12|396|0.03030,LIHC|2|373|0.00536,PAAD|1|185|0.00541
-chr9137328331137328331CTexonicRXRAsynonymous LUSC|1|178|0.00562
-chr9137300840137300840CTexonicRXRAnonsynonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122,STAD|1|395|0.00253,STES|1|395|0.00253
-chr9137300846137300846GAexonicRXRAnonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr9137328348137328348GAexonicRXRAnonsynonymous HNSC|1|512|0.00195
-chr9137328399137328399GAexonicRXRAnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr9137309089137309089GAexonicRXRAsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr9137328333137328333GAexonicRXRAnonsynonymous HNSC|1|512|0.00195

Disease information of RXRA
TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source
RXRA Prostatic Neoplasms C04;C12 Neoplastic Process CTD_human
RXRA Thyroid Neoplasm C04;C19 Neoplastic Process CTD_human
RXRA Sciatic Neuropathy C10 Disease or Syndrome CTD_human
RXRA Thyroid Gland Follicular Adenoma C04;C19 Neoplastic Process CTD_human
RXRA Lesion of Sciatic Nerve C10 Disease or Syndrome CTD_human
RXRA Sciatic Neuritis C10 Disease or Syndrome CTD_human
RXRA Malignant mesothelioma C04;C08 Neoplastic Process CTD_human
RXRA Malignant neoplasm of prostate C04;C12 Neoplastic Process CTD_human
RXRA Thyroid carcinoma C04;C19 Neoplastic Process CTD_human
RXRA Neuralgia-Neuritis, Sciatic Nerve C10 Disease or Syndrome CTD_human
RXRA Sciatic Nerve Palsy C10 Disease or Syndrome CTD_human
RXRA AMYOTROPHIC LATERAL SCLEROSIS 1 C10;C18 Disease or Syndrome CTD_human
RXRA Amyotrophic Lateral Sclerosis, Sporadic C10;C18 Disease or Syndrome CTD_human

Pathway associated with RXRA
pathway_ID pathway_name pathway_source gene_number edge_number
pathway0000044 a6b1 and a6b4 Integrin signaling pid 46 383
pathway0000069 Activation of gene expression by SREBF (SREBP) reactome 42 266
pathway0000316 BMAL1:CLOCK,NPAS2 activates circadian gene expression reactome 42 282
pathway0000430 Circadian Clock reactome 49 389
pathway0000664 Endogenous sterols reactome 22 41
pathway0001140 Import of palmitoyl-CoA into the mitochondrial matrix reactome 11 30
pathway0001815 Recycling of bile acids and salts reactome 15 37
pathway0001825 Regulation of Androgen receptor activity pid 54 338
pathway0001846 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) reactome 20 122
pathway0001853 Regulation of pyruvate dehydrogenase (PDH) complex reactome 14 60
pathway0001883 Retinoic acid receptors-mediated signaling pid 30 235
pathway0001940 RORA activates gene expression reactome 27 204
pathway0001947 RXR and RAR heterodimerization with other nuclear receptor pid 26 164
pathway0002028 Signaling by Retinoic Acid reactome 20 78
pathway0002153 Synthesis of bile acids and bile salts reactome 7 17
pathway0002155 Synthesis of bile acids and bile salts via 27-hydroxycholesterol reactome 15 38
pathway0002156 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol reactome 24 87
pathway0002299 Transcriptional activation of mitochondrial biogenesis reactome 43 230
pathway0002431 Vitamin D metabolism and pathway panther 6 6
pathway0002460 YAP1- and WWTR1 (TAZ)-stimulated gene expression reactome 29 144
pathway0002561 PPAR signaling pathway kegg 67 520
pathway0002628 Adipocytokine signaling pathway kegg 65 539
pathway0002663 Thyroid cancer kegg 25 123
pathway0002669 Small cell lung cancer kegg 83 807
pathway0002670 Non-small cell lung cancer kegg 54 623

Go term information of RXRA
GO_term_name GO_term_type TF_name
GO_REGULATION_OF_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE BP RXRA
GO_PROTEIN_HOMOTETRAMERIZATION BP RXRA
GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DIFFERENTIATION BP RXRA
GO_MODIFICATION_OF_MORPHOLOGY_OR_PHYSIOLOGY_OF_OTHER_ORGANISM BP RXRA
GO_REGULATION_OF_MYELINATION BP RXRA
GO_RESPONSE_TO_AXON_INJURY BP RXRA
GO_MUSCLE_CELL_PROLIFERATION BP RXRA
GO_AXON_REGENERATION BP RXRA
GO_POSITIVE_REGULATION_OF_TRANSLATIONAL_INITIATION BP RXRA
GO_HORMONE_MEDIATED_SIGNALING_PATHWAY BP RXRA
GO_VENTRICULAR_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT BP RXRA
GO_MUSCLE_STRUCTURE_DEVELOPMENT BP RXRA
GO_MODIFICATION_BY_SYMBIONT_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY BP RXRA
GO_CARDIAC_MUSCLE_CELL_DIFFERENTIATION BP RXRA
GO_CARDIAC_MUSCLE_TISSUE_MORPHOGENESIS BP RXRA
GO_MUSCLE_ORGAN_MORPHOGENESIS BP RXRA
GO_ORGAN_GROWTH BP RXRA
GO_INTERACTION_WITH_HOST BP RXRA
GO_REGULATION_OF_REPRODUCTIVE_PROCESS BP RXRA
GO_BILE_ACID_AND_BILE_SALT_TRANSPORT BP RXRA
GO_CARDIAC_VENTRICLE_DEVELOPMENT BP RXRA
GO_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT BP RXRA
GO_RESPONSE_TO_VITAMIN_A BP RXRA
GO_MODULATION_BY_VIRUS_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY BP RXRA
GO_RESPONSE_TO_VITAMIN_D BP RXRA
GO_NEURON_PROJECTION_REGENERATION BP RXRA
GO_MATERNAL_PROCESS_INVOLVED_IN_FEMALE_PREGNANCY BP RXRA
GO_STRIATED_MUSCLE_CELL_PROLIFERATION BP RXRA
GO_RESPONSE_TO_RETINOIC_ACID BP RXRA
GO_HEART_GROWTH BP RXRA
GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_PROSTATE_GLAND_DEVELOPMENT BP RXRA
GO_PROSTATE_GLAND_DEVELOPMENT BP RXRA
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_INVOLVED_IN_CELLULAR_RESPONSE_TO_CHEMICAL_STIMULUS BP RXRA
GO_MATERNAL_PLACENTA_DEVELOPMENT BP RXRA
GO_PROSTATE_GLANDULAR_ACINUS_DEVELOPMENT BP RXRA
GO_MIDGUT_DEVELOPMENT BP RXRA
GO_VITAMIN_METABOLIC_PROCESS BP RXRA
GO_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY BP RXRA
GO_CIRCULATORY_SYSTEM_DEVELOPMENT BP RXRA
GO_EMBRYO_IMPLANTATION BP RXRA
GO_GLANDULAR_EPITHELIAL_CELL_DIFFERENTIATION BP RXRA
GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_COMPLEX CC RXRA
GO_TRANSCRIPTION_FACTOR_COMPLEX CC RXRA
GO_NUCLEAR_TRANSCRIPTION_FACTOR_COMPLEX CC RXRA
GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING MF RXRA
GO_REGULATORY_REGION_NUCLEIC_ACID_BINDING MF RXRA
GO_STEROID_HORMONE_RECEPTOR_ACTIVITY MF RXRA
GO_VITAMIN_D_RECEPTOR_BINDING MF RXRA
GO_RETINOIC_ACID_RECEPTOR_BINDING MF RXRA
GO_STRUCTURE_SPECIFIC_DNA_BINDING MF RXRA

Survival analysis of RXRA



Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of RXRA