Sample overview of KYSE510

Sample ID: Sample_02_228
Biosample type: Cell line
Tissue type: Oesophagus
Biosample name: KYSE510
Data source: NCBI GEO/SRA
GSE ID: GSE76859
Cancer type: Esophageal squamous cell carcinoma (ESCC)
CRC number: 1073
TF number of all CRCs: 45
TF list of all CRCs: SMAD3, KLF5, RXRA, SOX2, TP63, RUNX1, BCL6, TFAP2A, TGIF1, STAT3, EHF, ZBTB7B, NFE2L2, EGR1, SOX13, SP3, ELF3, PBX1, SOX15, ZNF219, JUNB, STAT6, KLF12, SREBF1, KLF3, FOSL2, IRF6, RARB, MYC, CEBPA, NR3C1, ZNF217, DLX1, NFATC4, RARG, TP73, FOXQ1, NFIB, HES1, NFE2L1, ZBTB7A, HOXC4, MNT, HOXC8, MAFG

The most representative CRC of KYSE510
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Relationship plot of CRC model
TF number of this CRC: 18
CRC socre: 767.0556
TF list of the most representative CRC
TF name TF family Frequency of TFs
BCL6 ZBTB 1018 / 1073
EGR1 zf-C2H2 630 / 1073
EHF ETS 652 / 1073
HOXC4 Homeobox 36 / 1073
KLF5 zf-C2H2 1073 / 1073
NFE2L2 TF_bZIP 630 / 1073
PBX1 Homeobox 484 / 1073
RUNX1 Runt 1046 / 1073
RXRA RXR-like 1051 / 1073
SMAD3 MH1 1073 / 1073
SOX13 HMG 614 / 1073
SOX15 HMG 457 / 1073
SOX2 HMG 1046 / 1073
SP3 zf-C2H2 611 / 1073
TFAP2A AP-2 932 / 1073
TGIF1 Homeobox 760 / 1073
TP63 P53 1046 / 1073
ZBTB7B ZBTB 648 / 1073

All CRCs of KYSE510
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CRC rank TF list of CRCs CRC score TF number of CRC Detail of CRC

Frequency of TFs that appear in CRCs
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TF name Frequency of TFs TF family Ensembl ID
KLF5 1073 / 1073 zf-C2H2 ENSG00000102554
SMAD3 1073 / 1073 MH1 ENSG00000166949
RXRA 1051 / 1073 RXR-like ENSG00000186350
RUNX1 1046 / 1073 Runt ENSG00000159216
SOX2 1046 / 1073 HMG ENSG00000181449
TP63 1046 / 1073 P53 ENSG00000073282
BCL6 1018 / 1073 ZBTB ENSG00000113916
TFAP2A 932 / 1073 AP-2 ENSG00000137203
TGIF1 760 / 1073 Homeobox ENSG00000177426
STAT3 699 / 1073 STAT ENSG00000168610
EHF 652 / 1073 ETS ENSG00000135373
ZBTB7B 648 / 1073 ZBTB ENSG00000160685
NFE2L2 630 / 1073 TF_bZIP ENSG00000116044
EGR1 630 / 1073 zf-C2H2 ENSG00000120738
SOX13 614 / 1073 HMG ENSG00000143842
SP3 611 / 1073 zf-C2H2 ENSG00000172845
ELF3 550 / 1073 ETS ENSG00000163435
PBX1 484 / 1073 Homeobox ENSG00000185630
SOX15 457 / 1073 HMG ENSG00000129194
ZNF219 445 / 1073 zf-C2H2 ENSG00000165804
JUNB 430 / 1073 TF_bZIP ENSG00000171223
STAT6 430 / 1073 STAT ENSG00000166888
KLF12 422 / 1073 zf-C2H2 ENSG00000118922
SREBF1 390 / 1073 bHLH ENSG00000072310
KLF3 388 / 1073 zf-C2H2 ENSG00000109787
FOSL2 347 / 1073 TF_bZIP ENSG00000075426
IRF6 331 / 1073 IRF ENSG00000117595
RARB 322 / 1073 THR-like ENSG00000077092
MYC 288 / 1073 bHLH ENSG00000136997
CEBPA 266 / 1073 TF_bZIP ENSG00000245848
NR3C1 259 / 1073 ESR-like ENSG00000113580
ZNF217 255 / 1073 zf-C2H2 ENSG00000171940
DLX1 241 / 1073 Homeobox ENSG00000144355
NFATC4 212 / 1073 RHD ENSG00000100968
RARG 168 / 1073 THR-like ENSG00000172819
TP73 149 / 1073 P53 ENSG00000078900
FOXQ1 148 / 1073 Fork_head ENSG00000164379
NFIB 91 / 1073 CTF/NFI ENSG00000147862
HES1 69 / 1073 bHLH ENSG00000114315
NFE2L1 49 / 1073 TF_bZIP ENSG00000082641
ZBTB7A 43 / 1073 ZBTB ENSG00000178951
HOXC4 36 / 1073 Homeobox ENSG00000198353
MNT 27 / 1073 bHLH ENSG00000070444
HOXC8 22 / 1073 Homeobox ENSG00000037965
MAFG 11 / 1073 TF_bZIP ENSG00000197063

Indegree and outdegree of TFs
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TF name Indegree Outdegree Node connections
HOXC8 32 38 70
ZNF217 47 48 95
EGR1 46 58 104
NFATC4 41 54 95
JUNB 44 53 97
ZNF219 41 57 98
HOXC4 32 42 74
SMAD3 49 58 107
SOX2 47 58 105
ELF3 43 58 101
MAFG 40 34 74
STAT6 43 55 98
CEBPA 46 48 94
RARB 41 57 98
STAT3 46 55 101
TFAP2A 46 59 105
NFE2L2 48 57 105
NFE2L1 42 39 81
SOX13 43 59 102
MNT 48 33 81
SOX15 44 58 102
KLF5 49 58 107
RUNX1 48 59 107
KLF3 44 54 98
FOSL2 44 53 97
TP63 48 59 107
MYC 48 53 101
DLX1 46 47 93
FOXQ1 41 52 93
NR3C1 38 58 96
SP3 40 59 99
ZBTB7A 47 42 89
ZBTB7B 45 56 101
RARG 38 57 95
RXRA 48 59 107
EHF 46 58 104
KLF12 44 56 100
PBX1 48 52 100
NFIB 42 46 88
IRF6 46 46 92
TP73 40 43 83
SREBF1 45 58 103
HES1 44 48 92
BCL6 46 59 105
TGIF1 46 57 103

Expression of TFs in all CRCs