TF information

TF name: RARB
TF family: THR-like
Ensembl gene ID: ENSG00000077092
Ensembl protein ID: ENSP00000332296, ENSP00000373282, ENSP00000391391, ENSP00000398840
Entrez gene ID: 5915
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:

Frequency of RARB in all biosamples
Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_02_182Cell lineHuman melanomaLOX-IMVI0.077586206896552
Sample_02_228Cell lineOesophagusKYSE5100.30009319664492
Sample_02_268Cell lineKidneyA-4980.31124238508399

RARB distribution in samples’ most representative CRC
Sample ID Tissue type Biosample type Biosample name
Sample_02_268KidneyCell lineA-498

RARB distribution in all CRCs
Biosample type
Biosample name
Sample ID

Genomic distribution of SEs associated with RARB
Download

Mutation of RARB
Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of RARB

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
-chr32561139525611395GTexonicRARBnonsynonymous LUSC|1|178|0.00562
-chr32550281325502813GAexonicRARBnonsynonymous LUAD|1|543|0.00184
-chr32563791525637915ATexonicRARBsynonymous KIPAN|1|799|0.00125,KIRP|1|282|0.00355
-chr32561130125611301CTexonicRARBsynonymous HNSC|1|512|0.00195
-chr32521605325216053C-exonicRARBframeshift BLCA|1|396|0.00253
-chr32561133825611338CTexonicRARBnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr32562212425622124GAexonicRARBnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr32550271025502710GCexonicRARBnonsynonymous BRCA|1|982|0.00102
-chr32561130525611305GAexonicRARBnonsynonymous BLCA|1|396|0.00253
-chr32521595825215958CAexonicRARBnonsynonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122
-chr32563612925636129CGexonicRARBnonsynonymous SARC|1|247|0.00405
-chr32563796425637964CGexonicRARBnonsynonymous BLCA|1|396|0.00253
-chr32550282525502825GAexonicRARBnonsynonymous TGCT|1|155|0.00645
rs761412606chr32561128925611289GAexonicRARBsynonymous DLBC|1|48|0.02083
-chr32547011225470112ATUTR5RARBunknown BLCA|1|396|0.00253
-chr32563501225635012ACexonicRARBsynonymous UCEC|1|248|0.00403
-chr32550276425502764CAexonicRARBnonsynonymous LUAD|1|543|0.00184
rs756703369chr32521597725215977CTexonicRARBnonsynonymous SKCM|1|368|0.00272
-chr32554272925542729GCexonicRARBnonsynonymous BLCA|1|396|0.00253
-chr32550275925502759AGexonicRARBnonsynonymous ESCA|2|185|0.01081
-chr32563607725636077ACexonicRARBnonsynonymous CESC|1|194|0.00515
-chr32550277425502774TCexonicRARBnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr32563794025637940GAexonicRARBnonsynonymous SKCM|1|368|0.00272
-chr32550270825502708CAexonicRARBnonsynonymous BLCA|1|396|0.00253
-chr32550275525502755GAexonicRARBnonsynonymous PRAD|1|499|0.00200
-chr32562207225622072GAexonicRARBsynonymous BRCA|1|982|0.00102
-chr32554281125542811GTexonicRARBstopgain BRCA|1|982|0.00102
-chr32550271225502712GTexonicRARBnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs78062701chr32562214025622140GAexonicRARBnonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr32561130525611305GTexonicRARBstopgain KIPAN|2|799|0.00250,KIRC|2|451|0.00443
-chr32561134625611346GAexonicRARBsynonymous UCEC|1|248|0.00403
-chr32563499825634998TGexonicRARBnonsynonymous HNSC|1|512|0.00195
rs765012086chr32563519825635198GAexonicRARBnonsynonymous UCEC|1|248|0.00403
-chr32563501825635018AGexonicRARBnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr32521590225215902GAexonicRARBnonsynonymous LUAD|1|543|0.00184
-chr32554277025542770ACexonicRARBnonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr32554270525542705GAexonicRARBnonsynonymous LUAD|1|543|0.00184
-chr32554269625542696GTexonicRARBnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr32563792025637920GCexonicRARBnonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr32554275725542757AGexonicRARBnonsynonymous LUAD|1|543|0.00184
-chr32562213725622137ATexonicRARBnonsynonymous HNSC|1|512|0.00195,SKCM|1|368|0.00272
-chr32563796425637964CTexonicRARBnonsynonymous PAAD|1|185|0.00541
-chr32563606225636062TAexonicRARBstopgain SKCM|1|368|0.00272
-chr32550273125502731CTexonicRARBnonsynonymous BRCA|1|982|0.00102
-chr32554276125542761GAexonicRARBnonsynonymous UCEC|1|248|0.00403
rs767064867chr32521603125216031CTexonicRARBnonsynonymous SKCM|2|368|0.00543
rs372148180chr32561128825611288CTexonicRARBnonsynonymous BLCA|1|396|0.00253,COADREAD|1|489|0.00204,READ|1|122|0.00820
-chr32563615825636158TCexonicRARBnonsynonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
-chr32563505225635052GAexonicRARBnonsynonymous LUAD|1|543|0.00184
-chr32554276025542760CTexonicRARBstopgain COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr32550273525502735CAexonicRARBnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr32563506725635067GAexonicRARBnonsynonymous BRCA|1|982|0.00102
-chr32563796025637960AGexonicRARBsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr32561135425611354GAexonicRARBnonsynonymous SKCM|1|368|0.00272
-chr32550272625502726-CexonicRARBframeshift STAD|1|395|0.00253,STES|1|395|0.00253
-chr32561128425611284ATexonicRARBnonsynonymous PRAD|1|499|0.00200
-chr32550276925502769CAexonicRARBstopgain OV|1|469|0.00213
-chr32562219525622195CAexonicRARBsynonymous LUAD|1|543|0.00184
-chr32561137325611373TGexonicRARBsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr32563602525636025GCexonicRARBnonsynonymous LUSC|1|178|0.00562
-chr32562215425622154AGexonicRARBnonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr32554267625542676TCexonicRARBnonsynonymous LUSC|1|178|0.00562
-chr32563793325637933GCexonicRARBnonsynonymous CESC|1|194|0.00515
-chr32561129225611292GAexonicRARBsynonymous LUAD|1|543|0.00184
-chr32550278425502784CAexonicRARBnonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr32557291425572914-TAGATCGAintronicRARBunknown -
-chr32547033125470331TGexonicRARBnonsynonymous UCEC|1|248|0.00403
-chr32563508825635088GTexonicRARBnonsynonymous HNSC|1|512|0.00195
-chr32562205125622051CAexonicRARBnonsynonymous SARC|1|247|0.00405
-chr32563612325636123AGexonicRARBsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr32563610425636104G-exonicRARBframeshift CESC|1|194|0.00515
-chr32563793125637931TCexonicRARBsynonymous BLCA|1|396|0.00253
-chr32547023825470238GAexonicRARBnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr32563609725636097CTexonicRARBstopgain COAD|2|367|0.00545,COADREAD|2|489|0.00409
-chr32521597625215976CGexonicRARBnonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr32550274725502747CGexonicRARBnonsynonymous SARC|1|247|0.00405
-chr32563806925638069GCexonicRARBnonsynonymous BLCA|1|396|0.00253
-chr32521599325215993ATexonicRARBsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs748638067chr32521590725215907GAexonicRARBnonsynonymous PRAD|1|499|0.00200
-chr32554276525542765CAexonicRARBstopgain BRCA|1|982|0.00102
-chr32562218425622184CTexonicRARBsynonymous OV|1|469|0.00213
rs114613844chr32563517325635173CGexonicRARBsynonymous SKCM|1|368|0.00272
-chr32554280025542800GAexonicRARBnonsynonymous BRCA|1|982|0.00102
-chr32554280625542806CTexonicRARBnonsynonymous CESC|1|194|0.00515
-chr32550281825502818TAexonicRARBnonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr32561133525611335GAexonicRARBnonsynonymous SKCM|1|368|0.00272
-chr32550270625502706CAexonicRARBnonsynonymous PAAD|1|185|0.00541
-chr32547025925470259GTexonicRARBnonsynonymous BLCA|1|396|0.00253
rs750523929chr32521604725216047CTexonicRARBsynonymous ESCA|1|185|0.00541
-chr32554275325542753CTexonicRARBsynonymous LUAD|1|543|0.00184
-chr32521594325215943CTexonicRARBnonsynonymous SKCM|1|368|0.00272
-chr32554276625542766CGexonicRARBnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr32563506425635065AT-exonicRARBframeshift HNSC|1|512|0.00195
-chr32562205125622051CTexonicRARBsynonymous SARC|1|247|0.00405
-chr32547035125470351CTexonicRARBsynonymous BRCA|1|982|0.00102
-chr32562209025622090CTexonicRARBsynonymous BRCA|1|982|0.00102
rs372338731chr32550277325502773GAexonicRARBnonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr32554280425542804GTexonicRARBnonsynonymous HNSC|1|512|0.00195
-chr32563601025636010GAsplicingRARBsplicing COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr32562207525622075CGexonicRARBsynonymous LUAD|1|543|0.00184
-chr32563803825638038GAexonicRARBsynonymous UCEC|1|248|0.00403
-chr32563611325636113AGexonicRARBnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr32547033725470337G-exonicRARBframeshift LIHC|1|373|0.00268
-chr32563796225637962CAexonicRARBnonsynonymous LUAD|1|543|0.00184
-chr32562215725622157GTexonicRARBnonsynonymous LIHC|1|373|0.00268
-chr32554270525542705GCexonicRARBnonsynonymous CESC|1|194|0.00515
-chr32563791825637918GAexonicRARBsynonymous UCEC|1|248|0.00403
-chr32562205525622055CTexonicRARBstopgain COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr32562205725622057ATexonicRARBsynonymous BRCA|1|982|0.00102
rs773216330chr32562216925622169GAexonicRARBnonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr32563515425635154AGexonicRARBnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr32547029025470290CTexonicRARBnonsynonymous PRAD|1|499|0.00200
rs762241586chr32547028425470284CTexonicRARBnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr32547033525470335GAexonicRARBnonsynonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
rs768498439chr32547037825470378AGexonicRARBsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr32550275225502752CTexonicRARBstopgain UCEC|1|248|0.00403
-chr32550269225502692AGexonicRARBnonsynonymous COADREAD|1|489|0.00204,READ|1|122|0.00820
-chr32561130025611300GAexonicRARBnonsynonymous HNSC|1|512|0.00195
-chr32561128625611286TGexonicRARBsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs374139996chr32521603825216038GAexonicRARBsynonymous SKCM|1|368|0.00272
rs759614000chr32563615125636151CTexonicRARBnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204,STAD|1|395|0.00253,STES|1|395|0.00253

Disease information of RARB
TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source
RARB Adenocarcinoma C04 Neoplastic Process CTD_human
RARB Malignant neoplasm of breast C04;C17 Neoplastic Process CTD_human
RARB Squamous cell carcinoma C04 Neoplastic Process CTD_human
RARB Uterine Cervical Neoplasm C04;C13 Neoplastic Process CTD_human
RARB Congenital ocular coloboma (disorder) C11;C16 Congenital Abnormality GENOMICS_ENGLAND
RARB Endometriosis C13 Disease or Syndrome CTD_human
RARB Head and Neck Neoplasms C04 Neoplastic Process CTD_human
RARB Head Neoplasms C04 Neoplastic Process CTD_human
RARB Lung Neoplasms C04;C08 Neoplastic Process CTD_human
RARB Malignant neoplasm of stomach C04;C06 Neoplastic Process CTD_human
RARB Neck Neoplasms C04 Neoplastic Process CTD_human
RARB Stomach Neoplasms C04;C06 Neoplastic Process CTD_human
RARB Sciatic Neuropathy C10 Disease or Syndrome CTD_human
RARB Lesion of Sciatic Nerve C10 Disease or Syndrome CTD_human
RARB Adenocarcinoma, Basal Cell C04 Neoplastic Process CTD_human
RARB Adenocarcinoma, Oxyphilic C04 Neoplastic Process CTD_human
RARB Carcinoma, Cribriform C04 Neoplastic Process CTD_human
RARB Carcinoma, Granular Cell C04 Neoplastic Process CTD_human
RARB Adenocarcinoma, Tubular C04 Neoplastic Process CTD_human
RARB Sciatic Neuritis C10 Disease or Syndrome CTD_human
RARB Malignant neoplasm of lung C04;C08 Neoplastic Process CTD_human
RARB Endometrioma C13 Neoplastic Process CTD_human
RARB Malignant Head and Neck Neoplasm C04 Neoplastic Process CTD_human
RARB Breast Carcinoma C04;C17 Neoplastic Process CTD_human
RARB Cancer of Neck C04 Neoplastic Process CTD_human
RARB Cancer of Head C04 Neoplastic Process CTD_human
RARB Neuralgia-Neuritis, Sciatic Nerve C10 Disease or Syndrome CTD_human
RARB Sciatic Nerve Palsy C10 Disease or Syndrome CTD_human
RARB Upper Aerodigestive Tract Neoplasms C04 Neoplastic Process CTD_human
RARB Mammary Neoplasms, Human C04;C17 Neoplastic Process CTD_human
RARB Mammary Neoplasms C04;C17 Neoplastic Process CTD_human
RARB Colorectal Cancer C04;C06 Neoplastic Process UNIPROT
RARB Hereditary Diffuse Gastric Cancer C04;C06 Neoplastic Process CTD_human
RARB ANOPHTHALMIA AND PULMONARY HYPOPLASIA C08;C11;C16 Disease or Syndrome ORPHANET
RARB Intellectual Disability C10;C23;F01;F03 Mental or Behavioral Dysfunction GENOMICS_ENGLAND
RARB MICROPHTHALMIA, SYNDROMIC 12 Disease or Syndrome CTD_human;UNIPROT
RARB cervical cancer C04;C13 Neoplastic Process CTD_human

Pathway associated with RARB
pathway_ID pathway_name pathway_source gene_number edge_number
pathway0001534 Nuclear Receptor transcription pathway reactome 51 284
pathway0001883 Retinoic acid receptors-mediated signaling pid 30 235
pathway0001947 RXR and RAR heterodimerization with other nuclear receptor pid 26 164
pathway0002028 Signaling by Retinoic Acid reactome 20 78
pathway0002669 Small cell lung cancer kegg 83 807
pathway0002670 Non-small cell lung cancer kegg 54 623

Go term information of RARB
GO_term_name GO_term_type TF_name
GO_CARDIAC_CHAMBER_DEVELOPMENT BP RARB
GO_OUTFLOW_TRACT_SEPTUM_MORPHOGENESIS BP RARB
GO_CARTILAGE_DEVELOPMENT BP RARB
GO_REGULATION_OF_CARTILAGE_DEVELOPMENT BP RARB
GO_HINDLIMB_MORPHOGENESIS BP RARB
GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DIFFERENTIATION BP RARB
GO_REGULATION_OF_MYELINATION BP RARB
GO_BONE_GROWTH BP RARB
GO_GLANDULAR_EPITHELIAL_CELL_DEVELOPMENT BP RARB
GO_EMBRYONIC_DIGESTIVE_TRACT_DEVELOPMENT BP RARB
GO_HEART_MORPHOGENESIS BP RARB
GO_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION BP RARB
GO_EMBRYONIC_HINDLIMB_MORPHOGENESIS BP RARB
GO_NEGATIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT BP RARB
GO_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER BP RARB
GO_NEUROGENESIS BP RARB
GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DEVELOPMENT BP RARB
GO_CARTILAGE_DEVELOPMENT_INVOLVED_IN_ENDOCHONDRAL_BONE_MORPHOGENESIS BP RARB
GO_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY BP RARB
GO_UROGENITAL_SYSTEM_DEVELOPMENT BP RARB
GO_EMBRYONIC_EYE_MORPHOGENESIS BP RARB
GO_OUTFLOW_TRACT_MORPHOGENESIS BP RARB
GO_STRIATUM_DEVELOPMENT BP RARB
GO_POSITIVE_REGULATION_OF_CELL_DEVELOPMENT BP RARB
GO_ENDOCHONDRAL_BONE_MORPHOGENESIS BP RARB
GO_CARDIAC_SEPTUM_MORPHOGENESIS BP RARB
GO_RETINA_DEVELOPMENT_IN_CAMERA_TYPE_EYE BP RARB
GO_CELL_DEVELOPMENT BP RARB
GO_GROWTH_PLATE_CARTILAGE_DEVELOPMENT BP RARB
GO_EMBRYONIC_ORGAN_DEVELOPMENT BP RARB
GO_SUBPALLIUM_DEVELOPMENT BP RARB
GO_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY BP RARB
GO_NEGATIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION BP RARB
GO_GLANDULAR_EPITHELIAL_CELL_DIFFERENTIATION BP RARB
GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING MF RARB
GO_STEROID_HORMONE_RECEPTOR_ACTIVITY MF RARB
GO_RETINOIC_ACID_RECEPTOR_BINDING MF RARB
GO_RETINOID_X_RECEPTOR_BINDING MF RARB

Survival analysis of RARB



Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of RARB