TF information

TF name: DLX1
TF family: Homeobox
Ensembl gene ID: ENSG00000144355
Ensembl protein ID: ENSP00000354478, ENSP00000448827, ENSP00000354865
Entrez gene ID: 1745
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:

Frequency of DLX1 in all biosamples
Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_02_007OtherCervicalcervical-cancer_vector0.11920529801325
Sample_02_069Cell lineBrainSF2680.18320610687023
Sample_02_179Cell lineUrinary bladderT240.19540229885057
Sample_02_181Cell lineHuman melanomaCOLO6790.29546666666667
Sample_02_228Cell lineOesophagusKYSE5100.22460391425909
Sample_02_358Cell lineColonLS1800.22432859399684

DLX1 distribution in samples’ most representative CRC
Sample ID Tissue type Biosample type Biosample name

DLX1 distribution in all CRCs
Biosample type
Biosample name
Sample ID

Genomic distribution of SEs associated with DLX1
Download

Mutation of DLX1
Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of DLX1

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
-chr2172950625172950625TCexonicDLX1nonsynonymous BRCA|1|982|0.00102
-chr2172950494172950494TCexonicDLX1nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr2172952900172952900GAexonicDLX1nonsynonymous SKCM|1|368|0.00272
-chr2172950413172950413TAexonicDLX1nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr2172951530172951530TGexonicDLX1synonymous LUSC|1|178|0.00562
rs776516857chr2172950461172950461TCexonicDLX1nonsynonymous SKCM|1|368|0.00272
-chr2172952791172952791GCexonicDLX1nonsynonymous LUAD|1|543|0.00184
-chr2172952810172952810CTexonicDLX1nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr2172951422172951422ACexonicDLX1nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr2172950516172950516CTexonicDLX1synonymous SARC|1|247|0.00405
rs781303400chr2172950598172950598CAexonicDLX1synonymous KIPAN|1|799|0.00125,KIRP|1|282|0.00355
rs765307778chr2172952913172952913CTexonicDLX1synonymous SKCM|1|368|0.00272
-chr2172951487172951487TCexonicDLX1nonsynonymous ACC|1|90|0.01111
-chr2172951605172951605TCintronicDLX1unknown UCEC|1|248|0.00403
-chr2172951431172951431CTexonicDLX1synonymous BLCA|1|396|0.00253
-chr2172950420172950420CTexonicDLX1synonymous HNSC|1|512|0.00195
-chr2172952984172952984GAexonicDLX1synonymous UCEC|1|248|0.00403
-chr2172951500172951500CTexonicDLX1synonymous LUAD|1|543|0.00184
-chr2172952956172952956GCexonicDLX1nonsynonymous LUAD|2|543|0.00368
-chr2172950525172950525CTexonicDLX1synonymous UCEC|1|248|0.00403
rs541299088chr2172952820172952820CTexonicDLX1synonymous LUAD|1|543|0.00184
-chr2172950706172950706CGexonicDLX1nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs371818895chr2172951395172951395GAexonicDLX1synonymous HNSC|2|512|0.00391
-chr2172951798172951798GAintronicDLX1unknown UCEC|1|248|0.00403
rs773912946chr2172951506172951506GAexonicDLX1synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr2172952885172952885GAexonicDLX1nonsynonymous BLCA|1|396|0.00253
-chr2172952845172952845CTexonicDLX1nonsynonymous SKCM|1|368|0.00272
rs758527146chr2172952919172952919CAexonicDLX1synonymous LUAD|1|543|0.00184
-chr2172950416172950416CGexonicDLX1nonsynonymous SARC|1|247|0.00405
rs200336628chr2172952850172952850CGexonicDLX1synonymous SARC|1|247|0.00405

Disease information of DLX1
TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source
DLX1 Autistic Disorder F03 Mental or Behavioral Dysfunction CTD_human
DLX1 Bipolar Disorder F03 Mental or Behavioral Dysfunction PSYGENET
DLX1 Psychotic Disorders F03 Mental or Behavioral Dysfunction PSYGENET
DLX1 Schizophrenia F03 Mental or Behavioral Dysfunction PSYGENET
DLX1 Nonorganic psychosis Mental or Behavioral Dysfunction PSYGENET
DLX1 Craniofacial Abnormalities C05;C16 Congenital Abnormality CTD_human
DLX1 Autism Spectrum Disorders F03 Mental or Behavioral Dysfunction CTD_human

Pathway associated with DLX1
pathway_ID pathway_name pathway_source gene_number edge_number
pathway0001849 Regulation of nuclear SMAD2/3 signaling pid 82 1072

Go term information of DLX1
GO_term_name GO_term_type TF_name
GO_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS BP DLX1
GO_NEGATIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION BP DLX1
GO_NEGATIVE_REGULATION_OF_GLIOGENESIS BP DLX1
GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION BP DLX1
GO_NEGATIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY BP DLX1
GO_GABAERGIC_NEURON_DIFFERENTIATION BP DLX1
GO_FOREBRAIN_GENERATION_OF_NEURONS BP DLX1
GO_EMBRYO_DEVELOPMENT BP DLX1
GO_PROXIMAL_DISTAL_PATTERN_FORMATION BP DLX1
GO_CEREBRAL_CORTEX_NEURON_DIFFERENTIATION BP DLX1
GO_HIPPOCAMPUS_DEVELOPMENT BP DLX1
GO_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION BP DLX1
GO_CEREBRAL_CORTEX_GABAERGIC_INTERNEURON_DIFFERENTIATION BP DLX1
GO_REGULATION_OF_NOTCH_SIGNALING_PATHWAY BP DLX1
GO_REGULATION_OF_NEURON_DEATH BP DLX1
GO_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION BP DLX1
GO_NEURON_FATE_COMMITMENT BP DLX1
GO_FOREBRAIN_NEURON_FATE_COMMITMENT BP DLX1
GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_CELL_FATE_COMMITMENT BP DLX1
GO_SUBPALLIUM_DEVELOPMENT BP DLX1
GO_ODONTOGENESIS BP DLX1
GO_REGULATORY_REGION_NUCLEIC_ACID_BINDING MF DLX1

Survival analysis of DLX1



Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of DLX1