Cancer CRCdb

TF information

TF name:	NFE2L1
TF family:	TF_bZIP
Ensembl gene ID:	ENSG00000082641
Ensembl protein ID:	ENSP00000464446, ENSP00000463291, ENSP00000461960, ENSP00000445811, ENSP00000355190, ENSP00000354855, ENSP00000350072
Entrez gene ID:	4779

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of NFE2L1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_164	Cell line	Lung	H2087_Parental	0.2
Sample_02_228	Cell line	Oesophagus	KYSE510	0.045666356011184
Sample_02_268	Cell line	Kidney	A-498	0.019014214509876
Sample_02_296	Cell line	Neuroblastoma	CLB-BER-Lud	0.064269319051262
Sample_02_307	Cell line	Neuroblastoma	SJNB12	0.056338028169014
Sample_02_308	Cell line	Neuroblastoma	SJNB1	0.0625
Sample_02_309	Cell line	Neuroblastoma	SJNB6	0.028436018957346
Sample_02_310	Cell line	Neuroblastoma	SJNB8	0.015072083879423
Sample_02_316	Cell line	Neuroblastoma	CHP212	0.043956043956044

NFE2L1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name

NFE2L1 distribution in all CRCs

Genomic distribution of SEs associated with NFE2L1

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Mutation of NFE2L1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of NFE2L1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr17	46136464	46136464	G	A	exonic	NFE2L1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	46136577	46136577	C	T	exonic	NFE2L1	synonymous	BRCA\|1\|982\|0.00102,HNSC\|1\|512\|0.00195
-	chr17	46136644	46136644	C	T	exonic	NFE2L1	nonsynonymous	SKCM\|1\|368\|0.00272
rs773403681	chr17	46128958	46128958	-	C	exonic	NFE2L1	frameshift	BRCA\|1\|982\|0.00102,LIHC\|1\|373\|0.00268,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	46134780	46134780	C	T	exonic	NFE2L1	synonymous	SKCM\|1\|368\|0.00272
-	chr17	46128663	46128663	C	A	exonic	NFE2L1	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr17	46136934	46136934	C	T	exonic	NFE2L1	synonymous	BLCA\|1\|396\|0.00253,HNSC\|1\|512\|0.00195
-	chr17	46128887	46128887	C	A	exonic	NFE2L1	nonsynonymous	PRAD\|2\|499\|0.00401
-	chr17	46128819	46128819	C	T	exonic	NFE2L1	synonymous	SKCM\|1\|368\|0.00272
-	chr17	46136365	46136365	C	G	exonic	NFE2L1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr17	46135675	46135675	T	C	exonic	NFE2L1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	46135815	46135815	C	G	exonic	NFE2L1	synonymous	CESC\|1\|194\|0.00515
-	chr17	46136822	46136822	A	C	exonic	NFE2L1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr17	46138014	46138014	G	A	UTR3	NFE2L1	unknown	CESC\|1\|194\|0.00515
-	chr17	46134846	46134846	G	A	exonic	NFE2L1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	46136893	46136893	C	T	exonic	NFE2L1	stopgain	BRCA\|1\|982\|0.00102
rs141933946	chr17	46128597	46128597	C	T	exonic	NFE2L1	synonymous	LUAD\|2\|543\|0.00368
-	chr17	46128574	46128574	C	T	exonic	NFE2L1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	46136270	46136276	ACTCTGA	-	exonic	NFE2L1	frameshift	HNSC\|1\|512\|0.00195
-	chr17	46135680	46135680	A	G	exonic	NFE2L1	synonymous	SKCM\|1\|368\|0.00272
-	chr17	46136904	46136904	C	T	exonic	NFE2L1	synonymous	BRCA\|1\|982\|0.00102
-	chr17	46136186	46136186	C	T	exonic	NFE2L1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr17	46136806	46136806	C	T	exonic	NFE2L1	stopgain	ESCA\|1\|185\|0.00541
-	chr17	46136202	46136212	TTCTTCCTCTG	-	exonic	NFE2L1	frameshift	CHOL\|1\|35\|0.02857
rs761037568	chr17	46133897	46133897	C	T	exonic	NFE2L1	synonymous	UCEC\|1\|248\|0.00403
-	chr17	46134783	46134783	G	A	exonic	NFE2L1	synonymous	SKCM\|1\|368\|0.00272
-	chr17	46136612	46136612	C	T	exonic	NFE2L1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr17	46128703	46128703	G	A	exonic	NFE2L1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr17	46135950	46135950	C	G	exonic	NFE2L1	synonymous	LUAD\|1\|543\|0.00184
rs753941771	chr17	46136184	46136184	T	C	exonic	NFE2L1	synonymous	LIHC\|1\|373\|0.00268
rs150656110	chr17	46128928	46128928	G	A	exonic	NFE2L1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr17	46128846	46128846	C	T	exonic	NFE2L1	synonymous	HNSC\|1\|512\|0.00195,LUAD\|1\|543\|0.00184
-	chr17	46136179	46136179	T	C	exonic	NFE2L1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr17	46128617	46128617	C	G	exonic	NFE2L1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs144484468	chr17	46136768	46136768	G	A	exonic	NFE2L1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs773954893	chr17	46135824	46135824	C	T	exonic	NFE2L1	synonymous	SKCM\|1\|368\|0.00272
-	chr17	46135808	46135808	T	C	exonic	NFE2L1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr17	46137781	46137781	C	T	UTR3	NFE2L1	unknown	CESC\|1\|194\|0.00515
-	chr17	46128746	46128746	C	A	exonic	NFE2L1	nonsynonymous	HNSC\|2\|512\|0.00391
-	chr17	46133807	46133807	G	T	exonic	NFE2L1	nonsynonymous	PAAD\|1\|185\|0.00541
rs181240962	chr17	46135782	46135782	G	A	exonic	NFE2L1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	46128992	46128992	T	G	splicing	NFE2L1	splicing	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr17	46128984	46128984	C	T	exonic	NFE2L1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	46133885	46133885	G	T	exonic	NFE2L1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr17	46135877	46135877	C	A	exonic	NFE2L1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr17	46133814	46133814	G	-	exonic	NFE2L1	frameshift	BLCA\|1\|396\|0.00253
-	chr17	46128976	46128976	G	T	exonic	NFE2L1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr17	46136684	46136684	C	T	exonic	NFE2L1	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr17	46136906	46136906	A	T	exonic	NFE2L1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr17	46135695	46135695	C	T	exonic	NFE2L1	synonymous	BLCA\|1\|396\|0.00253
-	chr17	46134732	46134732	A	T	exonic	NFE2L1	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
rs766791282	chr17	46136913	46136913	C	T	exonic	NFE2L1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	46135997	46135997	-	G	exonic	NFE2L1	frameshift	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443
-	chr17	46133882	46133882	C	T	exonic	NFE2L1	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr17	46138017	46138017	G	A	UTR3	NFE2L1	unknown	CESC\|1\|194\|0.00515
-	chr17	46128959	46128959	C	-	exonic	NFE2L1	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
rs199935106	chr17	46128694	46128694	A	G	exonic	NFE2L1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr17	46133761	46133761	T	A	exonic	NFE2L1	nonsynonymous	BRCA\|1\|982\|0.00102
rs376772324	chr17	46136685	46136685	G	A	exonic	NFE2L1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	46135787	46135787	-	G	exonic	NFE2L1	frameshift	LUAD\|5\|543\|0.00921
-	chr17	46133894	46133894	G	T	exonic	NFE2L1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr17	46136441	46136441	C	T	exonic	NFE2L1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr17	46136986	46136986	A	G	exonic	NFE2L1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr17	46128581	46128581	C	G	exonic	NFE2L1	stopgain	BRCA\|1\|982\|0.00102
-	chr17	46136299	46136299	G	A	exonic	NFE2L1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	46136805	46136805	G	A	exonic	NFE2L1	synonymous	BRCA\|1\|982\|0.00102
-	chr17	46135788	46135788	G	-	exonic	NFE2L1	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr17	46136064	46136064	C	T	exonic	NFE2L1	synonymous	BRCA\|1\|982\|0.00102
-	chr17	46134756	46134756	-	C	exonic	NFE2L1	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	46135825	46135825	G	T	exonic	NFE2L1	stopgain	HNSC\|1\|512\|0.00195
rs770429052	chr17	46136124	46136124	C	T	exonic	NFE2L1	synonymous	CESC\|1\|194\|0.00515,SKCM\|1\|368\|0.00272
-	chr17	46133781	46133781	G	A	exonic	NFE2L1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr17	46136446	46136446	G	T	exonic	NFE2L1	nonsynonymous	SKCM\|1\|368\|0.00272
rs374254839	chr17	46134843	46134843	C	T	exonic	NFE2L1	synonymous	ESCA\|1\|185\|0.00541
-	chr17	46136841	46136842	GG	-	exonic	NFE2L1	frameshift	UCEC\|1\|248\|0.00403
-	chr17	46135698	46135698	T	C	exonic	NFE2L1	synonymous	LUSC\|1\|178\|0.00562
rs750380583	chr17	46128553	46128553	C	T	exonic	NFE2L1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr17	46135912	46135912	T	G	exonic	NFE2L1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	46136162	46136162	C	T	exonic	NFE2L1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr17	46135813	46135813	C	T	exonic	NFE2L1	nonsynonymous	CESC\|1\|194\|0.00515
rs769536773	chr17	46136901	46136901	G	C	exonic	NFE2L1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	46135813	46135813	C	G	exonic	NFE2L1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr17	46136797	46136797	C	T	exonic	NFE2L1	nonsynonymous	UCEC\|1\|248\|0.00403
rs772693788	chr17	46136395	46136395	G	A	exonic	NFE2L1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs369510266	chr17	46136704	46136704	C	T	exonic	NFE2L1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	46136540	46136540	G	A	exonic	NFE2L1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr17	46134725	46134725	G	T	exonic	NFE2L1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr17	46128721	46128721	C	A	exonic	NFE2L1	synonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr17	46128755	46128755	G	T	exonic	NFE2L1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr17	46133791	46133791	-	G	exonic	NFE2L1	frameshift	LUAD\|1\|543\|0.00184
-	chr17	46136011	46136011	G	C	exonic	NFE2L1	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr17	46136559	46136559	C	T	exonic	NFE2L1	synonymous	OV\|1\|469\|0.00213
-	chr17	46136555	46136555	C	G	exonic	NFE2L1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	46136643	46136643	C	T	exonic	NFE2L1	synonymous	SKCM\|1\|368\|0.00272
-	chr17	46136273	46136273	C	G	exonic	NFE2L1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	46135878	46135878	C	T	exonic	NFE2L1	synonymous	LUSC\|1\|178\|0.00562
-	chr17	46128683	46128683	A	G	exonic	NFE2L1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr17	46128610	46128610	C	A	exonic	NFE2L1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820

Disease information of NFE2L1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source

Pathway associated with NFE2L1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number

Go term information of NFE2L1

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GO_term_name	GO_term_type	TF_name
GO_MYELOID_CELL_HOMEOSTASIS	BP	NFE2L1
GO_ERYTHROCYTE_HOMEOSTASIS	BP	NFE2L1
GO_HEME_METABOLIC_PROCESS	BP	NFE2L1
GO_TETRAPYRROLE_BIOSYNTHETIC_PROCESS	BP	NFE2L1
GO_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS	BP	NFE2L1
GO_PIGMENT_BIOSYNTHETIC_PROCESS	BP	NFE2L1
GO_HEME_BIOSYNTHETIC_PROCESS	BP	NFE2L1
GO_COFACTOR_BIOSYNTHETIC_PROCESS	BP	NFE2L1
GO_PIGMENT_METABOLIC_PROCESS	BP	NFE2L1
GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING	MF	NFE2L1
GO_ENHANCER_BINDING	MF	NFE2L1
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING	MF	NFE2L1

Survival analysis of NFE2L1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of NFE2L1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)